skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Asthma prevalence in Portuguese preschool children: The latest scientific evidence

; ; ; ; ; ;
Publication Date:
Sponsoring Org.:
USDOE Office of Nuclear Energy (NE), Fuel Cycle Technologies (NE-5)
OSTI Identifier:
Resource Type:
Journal Article: Published Article
Journal Name:
Revista Portuguesa de Pneumologia (English Edition)
Additional Journal Information:
Journal Name: Revista Portuguesa de Pneumologia (English Edition); Journal Volume: 22; Journal Issue: 5; Related Information: CHORUS Timestamp: 2016-09-09 04:25:50; Journal ID: ISSN 2173-5115
Country of Publication:
Country unknown/Code not available

Citation Formats

Branco, P. T. B. S., Nunes, R. A. O., Alvim-Ferraz, M. C. M., Martins, F. G., Ferraz, C., Vaz, L. G., and Sousa, S. I. V. Asthma prevalence in Portuguese preschool children: The latest scientific evidence. Country unknown/Code not available: N. p., 2016. Web. doi:10.1016/j.rppnen.2016.03.013.
Branco, P. T. B. S., Nunes, R. A. O., Alvim-Ferraz, M. C. M., Martins, F. G., Ferraz, C., Vaz, L. G., & Sousa, S. I. V. Asthma prevalence in Portuguese preschool children: The latest scientific evidence. Country unknown/Code not available. doi:10.1016/j.rppnen.2016.03.013.
Branco, P. T. B. S., Nunes, R. A. O., Alvim-Ferraz, M. C. M., Martins, F. G., Ferraz, C., Vaz, L. G., and Sousa, S. I. V. 2016. "Asthma prevalence in Portuguese preschool children: The latest scientific evidence". Country unknown/Code not available. doi:10.1016/j.rppnen.2016.03.013.
title = {Asthma prevalence in Portuguese preschool children: The latest scientific evidence},
author = {Branco, P. T. B. S. and Nunes, R. A. O. and Alvim-Ferraz, M. C. M. and Martins, F. G. and Ferraz, C. and Vaz, L. G. and Sousa, S. I. V.},
abstractNote = {},
doi = {10.1016/j.rppnen.2016.03.013},
journal = {Revista Portuguesa de Pneumologia (English Edition)},
number = 5,
volume = 22,
place = {Country unknown/Code not available},
year = 2016,
month = 9

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record at 10.1016/j.rppnen.2016.03.013

Citation Metrics:
Cited by: 1work
Citation information provided by
Web of Science

Save / Share:
  • A diary study on a random sample of 625 Swiss children aged 0 to 5 yr was conducted in two cities in Switzerland to investigate the association between air pollution and respiratory symptoms. Total suspended particulates (TSP), SO2 and NO2 were measured by city monitor. In addition, passive samplers inside and outside the home measured NO2 concentration during the 6 wk each child was on the diary. Diaries were filled out by parents, and 20% were validated with the attending pediatrician's case notes. Incidence and duration of symptom episodes were examined separately. The study included any episode, episodes of coughingmore » without runny nose, upper respiratory episodes, and episodes of breathing difficulty. In regressions using 6-wk average pollution that controlled for medical history, NO2 measured outdoors but not indoors was associated with the duration of any symptom. Total suspended particulates were a more significant predictor of duration of any symptom than NO2. The 6-wk average TSP was significantly associated with incidence of coughing episodes and marginally significant as a predictor of upper respiratory episodes. Previous day's TSP was a significant predictor of incidence of upper respiratory symptoms. Annual average of NO2 was associated with the duration of any episode and of upper respiratory episodes. We conclude that the incidence and duration of respiratory symptom episodes are likely associated with particulate concentrations and duration may be associated with NO2.« less
  • A nationwide, seven-day food consumption survey of 371 preschool children between the ages of birth and five years indicated that a direct linear relationship existed between age and increased dietary lead intake from foods consumed. Daily dietary lead intake averaged 62 and ranged from 15 to 234 The various levels of lead intake were attributed to frequency of consumption of food items, quantity of food consumed, and the lead content of particular food items. To account for variation in the quantity of food consumed by the various children, average lead intake per 500 kilocalories consumed and permore » 500 g of food consumed was calculated. When these standardization procedures were followed, an equalization in the average daily dietary lead intake values was observed among the various aged children.« less
  • The purpose of this study is to describe the total hair mercury concentrations and their determinants in preschool Spanish children, as well as to explore the trend in mercury exposure from birth to the age four. This evolution has been scarcely studied in other birth cohort studies. The study population was 580 four year old children participating in the INMA (i.e. Childhood and Environment) birth cohort study in Valencia (2008–2009). Total mercury concentration at age four was measured in hair samples by atomic absorption spectrometry. Fish consumption and other covariates were obtained by questionnaire. Multivariate linear regression models were conductedmore » in order to explore the association between mercury exposure and fish consumption, socio-demographic characteristics and prenatal exposure to mercury. The geometric mean was 1.10 µg/g (95%CI: 1.02, 1.19). Nineteen percent of children had mercury concentrations above the equivalent to the Provisional Tolerable Weekly Intake proposed by WHO. Mercury concentration was associated with increasing maternal age, fish consumption and cord blood mercury levels, as well as decreasing parity. Children whose mothers worked had higher mercury levels than those with non working mothers. Swordfish, lean fish and canned fish were the fish categories most associated with hair mercury concentrations. We observed a decreasing trend in mercury concentrations between birth and age four. In conclusion, the children participating in this study had high hair mercury concentrations compared to reported studies on children from other European countries and similar to other countries with high fish consumption. The INMA study design allows the evaluation of the exposure to mercury longitudinally and enables this information to be used for biomonitoring purposes and dietary recommendations. - Highlights: • The geometric mean of hair Hg concentrations was 1.10 µg/g. • 19% of children had Hg concentrations above the RfD proposed by the WHO. • Hair Hg concentrations in children increased as a function of total fish intake. • Swordfish, lean fish and canned fish were the most related to Hg concentrations. • There was a decrease in Hg concentrations from birth to age four.« less
  • Background: Early-life exposure to toxic compounds may cause long-lasting health effects, but few studies have investigated effects of childhood exposure to nephrotoxic metals on kidney and cardiovascular function. Objectives: To assess effects of exposure to arsenic and cadmium on kidney function and blood pressure in pre-school-aged children, and potential protection by selenium. Methods: This cross-sectional study was part of the 4.5 years of age (range: 4.4–5.4 years) follow-up of the children from a supplementation trial in pregnancy (MINIMat) in rural Bangladesh, and nested studies on early-life metal exposures. Exposure to arsenic, cadmium and selenium from food and drinking water wasmore » assessed by concentrations in children's urine, measured by ICP-MS. Kidney function was assessed by the estimated glomerular filtration rate (eGFR, n=1106), calculated from serum cystatin C, and by kidney volume, measured by ultrasound (n=375). Systolic and diastolic blood pressure was measured (n=1356) after five minutes rest. Results: Multivariable-adjusted regression analyzes showed that exposure to cadmium, but not arsenic, was inversely associated with eGFR, particularly in girls. A 0.5 µg/L increase in urinary cadmium among the girls (above spline knot at 0.12) was associated with a decrease in eGFR of 2.6 ml/min/1.73 m{sup 2}, corresponding to 0.2SD (p=0.022). A slightly weaker inverse association with cadmium was also indicated for kidney volume, but no significant associations were found with blood pressure. Stratifying on children's urinary selenium (below or above median of 12.6 µg/L) showed a three times stronger inverse association of U-Cd with eGFR (all children) in the lower selenium stratum (B=−2.8; 95% CI: −5.5, −0.20; p=0.035), compared to those with higher selenium (B=−0.79; 95% CI: −3.0, 1.4; p=0.49). Conclusions: Childhood cadmium exposure seems to adversely affect kidney function, but not blood pressure, in this population of young children in rural Bangladesh. Better selenium status appears to be protective. However, it is important to follow up these children to assess potential long-term consequences of these findings. - Highlights: • Bangladesh has high levels of arsenic and cadmium in drinking water and food • We assessed toxic exposure, kidney and cardiovascular function in Bangladeshi children • Cadmium appeared to decrease estimated glomerular filtration rate in girls • These effects were somewhat alleviated by selenium.« less