skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: The crystal structure of human GlnRS provides basis for the development of neurological disorders

Authors:
; ; ; ; ; ; ; ;  [1]
  1. Texas
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
DOE - BASIC ENERGY SCIENCES
OSTI Identifier:
1252773
Resource Type:
Journal Article
Journal Name:
Nucleic Acids Research
Additional Journal Information:
Journal Volume: 44; Journal Issue: (7) ; 04, 2016; Journal ID: ISSN 0305-1048
Publisher:
Oxford University Press
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Ognjenovi,, #263, Jana,, Wu, Jiang, Matthies, Doreen, Baxa, Ulrich, Subramaniam, Sriram, Ling, Jiqiang, Simonovi,, #263, Miljan,, NCI), and UIC). The crystal structure of human GlnRS provides basis for the development of neurological disorders. United States: N. p., 2016. Web. doi:10.1093/nar/gkw082.
Ognjenovi,, #263, Jana,, Wu, Jiang, Matthies, Doreen, Baxa, Ulrich, Subramaniam, Sriram, Ling, Jiqiang, Simonovi,, #263, Miljan,, NCI), & UIC). The crystal structure of human GlnRS provides basis for the development of neurological disorders. United States. doi:10.1093/nar/gkw082.
Ognjenovi,, #263, Jana,, Wu, Jiang, Matthies, Doreen, Baxa, Ulrich, Subramaniam, Sriram, Ling, Jiqiang, Simonovi,, #263, Miljan,, NCI), and UIC). Tue . "The crystal structure of human GlnRS provides basis for the development of neurological disorders". United States. doi:10.1093/nar/gkw082.
@article{osti_1252773,
title = {The crystal structure of human GlnRS provides basis for the development of neurological disorders},
author = {Ognjenovi, and #263 and Jana, and Wu, Jiang and Matthies, Doreen and Baxa, Ulrich and Subramaniam, Sriram and Ling, Jiqiang and Simonovi, and #263 and Miljan, and NCI) and UIC)},
abstractNote = {},
doi = {10.1093/nar/gkw082},
journal = {Nucleic Acids Research},
issn = {0305-1048},
number = (7) ; 04, 2016,
volume = 44,
place = {United States},
year = {2016},
month = {5}
}

Works referenced in this record:

Aminoacyl-tRNA Synthesis
journal, June 2000


Mutational isolation of a sieve for editing in a transfer RNA synthetase
journal, April 1994


Human tRNA synthetase catalytic nulls with diverse functions
journal, July 2014


New functions of aminoacyl-tRNA synthetases beyond translation
journal, August 2010

  • Guo, Min; Yang, Xiang-Lei; Schimmel, Paul
  • Nature Reviews Molecular Cell Biology, Vol. 11, Issue 9
  • DOI: 10.1038/nrm2956

Unique domain appended to vertebrate tRNA synthetase is essential for vascular development
journal, January 2012

  • Xu, Xiaoling; Shi, Yi; Zhang, Hui-Min
  • Nature Communications, Vol. 3, Issue 1
  • DOI: 10.1038/ncomms1686

Aminoacyl‐tRNA synthetases in medicine and disease
journal, February 2013


The Role of Aminoacyl-tRNA Synthetases in Genetic Diseases
journal, September 2008


Glycyl tRNA Synthetase Mutations in Charcot-Marie-Tooth Disease Type 2D and Distal Spinal Muscular Atrophy Type V
journal, May 2003

  • Antonellis, Anthony; Ellsworth, Rachel E.; Sambuughin, Nyamkhishig
  • The American Journal of Human Genetics, Vol. 72, Issue 5
  • DOI: 10.1086/375039

Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy
journal, January 2006

  • Jordanova, Albena; Irobi, Joy; Thomas, Florian P.
  • Nature Genetics, Vol. 38, Issue 2
  • DOI: 10.1038/ng1727

A Major Determinant for Binding and Aminoacylation of tRNAAla in Cytoplasmic Alanyl-tRNA Synthetase Is Mutated in Dominant Axonal Charcot-Marie-Tooth Disease
journal, January 2010

  • Latour, Philippe; Thauvin-Robinet, Christel; Baudelet-Méry, Chantal
  • The American Journal of Human Genetics, Vol. 86, Issue 1
  • DOI: 10.1016/j.ajhg.2009.12.005

Compound Heterozygosity for Loss-of-Function Lysyl-tRNA Synthetase Mutations in a Patient with Peripheral Neuropathy
journal, October 2010

  • McLaughlin, Heather M.; Sakaguchi, Reiko; Liu, Cuiping
  • The American Journal of Human Genetics, Vol. 87, Issue 4
  • DOI: 10.1016/j.ajhg.2010.09.008

Genetic Mapping and Exome Sequencing Identify Variants Associated with Five Novel Diseases
journal, January 2012


Mutation of the Mitochondrial Tyrosyl-tRNA Synthetase Gene, YARS2, Causes Myopathy, Lactic Acidosis, and Sideroblastic Anemia—MLASA Syndrome
journal, July 2010

  • Riley, Lisa G.; Cooper, Sandra; Hickey, Peter
  • The American Journal of Human Genetics, Vol. 87, Issue 1
  • DOI: 10.1016/j.ajhg.2010.06.001

Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation
journal, March 2007

  • Scheper, Gert C.; van der Klok, Thom; van Andel, Rob J.
  • Nature Genetics, Vol. 39, Issue 4
  • DOI: 10.1038/ng2013

Leukoencephalopathy with thalamus and brainstem involvement and high lactate ‘LTBL’ caused by EARS2 mutations
journal, April 2012

  • Steenweg, Marjan E.; Ghezzi, Daniele; Haack, Tobias
  • Brain, Vol. 135, Issue 5
  • DOI: 10.1093/brain/aws070

Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome
journal, April 2011

  • Pierce, S. B.; Chisholm, K. M.; Lynch, E. D.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 16
  • DOI: 10.1073/pnas.1103471108

Mutations in LARS2, Encoding Mitochondrial Leucyl-tRNA Synthetase, Lead to Premature Ovarian Failure and Hearing Loss in Perrault Syndrome
journal, April 2013

  • Pierce, Sarah B.; Gersak, Ksenija; Michaelson-Cohen, Rachel
  • The American Journal of Human Genetics, Vol. 92, Issue 4
  • DOI: 10.1016/j.ajhg.2013.03.007

Deleterious Mutation in the Mitochondrial Arginyl–Transfer RNA Synthetase Gene Is Associated with Pontocerebellar Hypoplasia
journal, October 2007

  • Edvardson, Simon; Shaag, Avraham; Kolesnikova, Olga
  • The American Journal of Human Genetics, Vol. 81, Issue 4
  • DOI: 10.1086/521227

Further delineation of pontocerebellar hypoplasia type 6 due to mutations in the gene encoding mitochondrial arginyl-tRNA synthetase, RARS2
journal, November 2011

  • Glamuzina, Emma; Brown, Ruth; Hogarth, Kieran
  • Journal of Inherited Metabolic Disease, Vol. 35, Issue 3
  • DOI: 10.1007/s10545-011-9413-6

Mitochondrial phenylalanyl-tRNA synthetase mutations underlie fatal infantile Alpers encephalopathy
journal, July 2012

  • Elo, Jenni M.; Yadavalli, Srujana S.; Euro, Liliya
  • Human Molecular Genetics, Vol. 21, Issue 20
  • DOI: 10.1093/hmg/dds294

Mutations in DARS Cause Hypomyelination with Brain Stem and Spinal Cord Involvement and Leg Spasticity
journal, May 2013

  • Taft, Ryan J.; Vanderver, Adeline; Leventer, Richard J.
  • The American Journal of Human Genetics, Vol. 92, Issue 5
  • DOI: 10.1016/j.ajhg.2013.04.006

Exome Sequencing Links Corticospinal Motor Neuron Disease to Common Neurodegenerative Disorders
journal, January 2014


Essential nontranslational functions of tRNA synthetases
journal, February 2013


Transfer RNA and human disease
journal, June 2014

  • Abbott, Jamie A.; Francklyn, Christopher S.; Robey-Bond, Susan M.
  • Frontiers in Genetics, Vol. 5
  • DOI: 10.3389/fgene.2014.00158

Mutations in QARS, Encoding Glutaminyl-tRNA Synthetase, Cause Progressive Microcephaly, Cerebral-Cerebellar Atrophy, and Intractable Seizures
journal, April 2014

  • Zhang, Xiaochang; Ling, Jiqiang; Barcia, Giulia
  • The American Journal of Human Genetics, Vol. 94, Issue 4
  • DOI: 10.1016/j.ajhg.2014.03.003

Structure of E. coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP at 2.8 A resolution
journal, December 1989


Genetic dissection of protein-protein interactions in multi-tRNA synthetase complex
journal, April 1999

  • Rho, S. B.; Kim, M. J.; Lee, J. S.
  • Proceedings of the National Academy of Sciences, Vol. 96, Issue 8
  • DOI: 10.1073/pnas.96.8.4488

Catalytic Peptide of Human Glutaminyl-tRNA Synthetase Is Essential for Its Assembly to the Aminoacyl-tRNA Synthetase Complex
journal, May 2000

  • Kim, Taeho; Park, Sang Gyu; Kim, Jee Eun
  • Journal of Biological Chemistry, Vol. 275, Issue 28
  • DOI: 10.1074/jbc.M002404200

Glutamine-dependent Antiapoptotic Interaction of Human Glutaminyl-tRNA Synthetase with Apoptosis Signal-regulating Kinase 1
journal, November 2000

  • Ko, Young-Gyu; Kim, Eun-Kyoung; Kim, Taeho
  • Journal of Biological Chemistry, Vol. 276, Issue 8
  • DOI: 10.1074/jbc.M006189200

Structural conservation of an ancient tRNA sensor in eukaryotic glutaminyl-tRNA synthetase
journal, December 2011

  • Grant, Thomas D.; Snell, Edward H.; Luft, Joseph R.
  • Nucleic Acids Research, Vol. 40, Issue 8
  • DOI: 10.1093/nar/gkr1223

The Structure of Yeast Glutaminyl-tRNA Synthetase and Modeling of Its Interaction with tRNA
journal, July 2013

  • Grant, Thomas D.; Luft, Joseph R.; Wolfley, Jennifer R.
  • Journal of Molecular Biology, Vol. 425, Issue 14
  • DOI: 10.1016/j.jmb.2013.03.043

A short history of SHELX
journal, December 2007

  • Sheldrick, George M.
  • Acta Crystallographica Section A Foundations of Crystallography, Vol. 64, Issue 1, p. 112-122
  • DOI: 10.1107/S0108767307043930

Overview of the CCP 4 suite and current developments
journal, March 2011

  • Winn, Martyn D.; Ballard, Charles C.; Cowtan, Kevin D.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4
  • DOI: 10.1107/S0907444910045749

Histogram matching as a new density modification technique for phase refinement and extension of protein molecules
journal, January 1990

  • Zhang, K. Y. J.; Main, P.
  • Acta Crystallographica Section A Foundations of Crystallography, Vol. 46, Issue 1
  • DOI: 10.1107/S0108767389009311

PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

Coot model-building tools for molecular graphics
journal, November 2004

  • Emsley, Paul; Cowtan, Kevin
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
  • DOI: 10.1107/S0907444904019158

Protein structure alignment by incremental combinatorial extension (CE) of the optimal path
journal, September 1998

  • Shindyalov, I. N.; Bourne, P. E.
  • Protein Engineering Design and Selection, Vol. 11, Issue 9
  • DOI: 10.1093/protein/11.9.739

Two enzymes bound to one transfer RNA assume alternative conformations for consecutive reactions
journal, September 2010


Gene Descent, Duplication, and Horizontal Transfer in the Evolution of Glutamyl- and Glutaminyl-tRNA Synthetases
journal, October 1999

  • Brown, James R.; Doolittle, W. Ford
  • Journal of Molecular Evolution, Vol. 49, Issue 4
  • DOI: 10.1007/PL00006571

Systematic humanization of yeast genes reveals conserved functions and genetic modularity
journal, May 2015


Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme as a case of horizontal gene transfer.
journal, August 1994

  • Lamour, V.; Quevillon, S.; Diriong, S.
  • Proceedings of the National Academy of Sciences, Vol. 91, Issue 18
  • DOI: 10.1073/pnas.91.18.8670

Aminoacyl-tRNA Synthetases, the Genetic Code, and the Evolutionary Process
journal, March 2000


Structure of an archaeal non-discriminating glutamyl-tRNA synthetase: a missing link in the evolution of Gln-tRNAGln formation
journal, July 2010

  • Nureki, Osamu; O’Donoghue, Patrick; Watanabe, Nobuhisa
  • Nucleic Acids Research, Vol. 38, Issue 20
  • DOI: 10.1093/nar/gkq605

From one amino acid to another: tRNA-dependent amino acid biosynthesis
journal, February 2008

  • Sheppard, K.; Yuan, J.; Hohn, M. J.
  • Nucleic Acids Research, Vol. 36, Issue 6
  • DOI: 10.1093/nar/gkn015

Rational design of an evolutionary precursor of glutaminyl-tRNA synthetase
journal, December 2011

  • O'Donoghue, P.; Sheppard, K.; Nureki, O.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 51
  • DOI: 10.1073/pnas.1117294108

Mutations in the glutaminyl-tRNA synthetase gene cause early-onset epileptic encephalopathy
journal, December 2014

  • Kodera, Hirofumi; Osaka, Hitoshi; Iai, Mizue
  • Journal of Human Genetics, Vol. 60, Issue 2
  • DOI: 10.1038/jhg.2014.103

Expansion of the QARS deficiency phenotype with report of a family with isolated supratentorial brain abnormalities
journal, November 2014


tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia
journal, August 2008

  • Budde, Birgit S.; Namavar, Yasmin; Barth, Peter G.
  • Nature Genetics, Vol. 40, Issue 9
  • DOI: 10.1038/ng.204

Cellular strategies for controlling protein aggregation
journal, October 2010

  • Tyedmers, Jens; Mogk, Axel; Bukau, Bernd
  • Nature Reviews Molecular Cell Biology, Vol. 11, Issue 11
  • DOI: 10.1038/nrm2993

Converging concepts of protein folding in vitro and in vivo
journal, June 2009

  • Hartl, F. Ulrich; Hayer-Hartl, Manajit
  • Nature Structural & Molecular Biology, Vol. 16, Issue 6
  • DOI: 10.1038/nsmb.1591

    Works referencing / citing this record:

    Transcriptome profiling of aging Drosophila photoreceptors reveals gene expression trends that correlate with visual senescence
    journal, November 2017