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Title: Response to Comment on "Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism"

Abstract

Wang comments that the diffraction data for the structure of the A139T mutant of translocator protein TSPO from Rhodobacter sphaeroides should be used to 1.65 instead of 1.8 angstroms and that the density interpreted as porphyrin and monoolein is better fitted as polyethylene glycol. Although different practices of data processing exist, in this case they do not substantially influence the final map. Additional data are presented supporting the fit of a porphyrin and monooleins.

Authors:
 [1];  [1];  [1];  [1];  [1]
  1. Univ. of California, San Diego, CA (United States)
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1252754
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Science
Additional Journal Information:
Journal Volume: 350; Journal Issue: 6260; Journal ID: ISSN 0036-8075
Publisher:
AAAS
Country of Publication:
United States
Language:
ENGLISH
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Li, Fei, Liu, Jian, Zheng, Yi, Garavito, R. Michael, and Ferguson-Miller, Shelagh. Response to Comment on "Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism". United States: N. p., 2015. Web. doi:10.1126/science.aab2595.
Li, Fei, Liu, Jian, Zheng, Yi, Garavito, R. Michael, & Ferguson-Miller, Shelagh. Response to Comment on "Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism". United States. https://doi.org/10.1126/science.aab2595
Li, Fei, Liu, Jian, Zheng, Yi, Garavito, R. Michael, and Ferguson-Miller, Shelagh. 2015. "Response to Comment on "Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism"". United States. https://doi.org/10.1126/science.aab2595. https://www.osti.gov/servlets/purl/1252754.
@article{osti_1252754,
title = {Response to Comment on "Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism"},
author = {Li, Fei and Liu, Jian and Zheng, Yi and Garavito, R. Michael and Ferguson-Miller, Shelagh},
abstractNote = {Wang comments that the diffraction data for the structure of the A139T mutant of translocator protein TSPO from Rhodobacter sphaeroides should be used to 1.65 instead of 1.8 angstroms and that the density interpreted as porphyrin and monoolein is better fitted as polyethylene glycol. Although different practices of data processing exist, in this case they do not substantially influence the final map. Additional data are presented supporting the fit of a porphyrin and monooleins.},
doi = {10.1126/science.aab2595},
url = {https://www.osti.gov/biblio/1252754}, journal = {Science},
issn = {0036-8075},
number = 6260,
volume = 350,
place = {United States},
year = {Thu Oct 29 00:00:00 EDT 2015},
month = {Thu Oct 29 00:00:00 EDT 2015}
}

Journal Article:
Free Publicly Available Full Text
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Cited by: 12 works
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Works referenced in this record:

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Structure and activity of tryptophan-rich TSPO proteins
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PHENIX: a comprehensive Python-based system for macromolecular structure solution
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