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Title: Protein Arginine Deiminase 2 Binds Calcium in an Ordered Fashion: Implications for Inhibitor Design

Journal Article · · ACS Chemical Biology
DOI:https://doi.org/10.1021/cb500933j· OSTI ID:1251226

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
NIHOTHER
OSTI ID:
1251226
Journal Information:
ACS Chemical Biology, Vol. 10, Issue (4) ; 01, 2015; ISSN 1554-8929
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
ENGLISH

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Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity journal March 2014
Peptidylarginine deiminase: a candidate factor in demyelinating disease: A candidate factor in demyelinating disease journal April 2002
Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor   target gene activation journal August 2012
Dysregulation of PAD4-mediated citrullination of nuclear GSK3  activates TGF-  signaling and induces epithelial-to-mesenchymal transition in breast cancer cells journal July 2013
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Cited By (21)

Calcium coordination compounds based on phenoxyacetic acids: microwave synthesis, thermostability and influences on the crystal structures of chlorine substituent group on ligands journal January 2016
Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases journal January 2020
In vivo expression of peptidylarginine deiminase in Drosophila melanogaster journal January 2020
Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase journal July 2015
Autoantibodies to protein-arginine deiminase (PAD) 4 in rheumatoid arthritis: immunological and clinical significance, and potential for precision medicine: Anti-PAD4 antibodies in RA journal October 2019
Phosphorylation-dependent protein design: design of a minimal protein kinase-inducible domain journal January 2019
Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis journal October 2017
Protein-arginine deiminase 2 suppresses proliferation of colon cancer cells through protein citrullination journal April 2017
Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans journal August 2019
Halogen Bonding Increases the Potency and Isozyme Selectivity of Protein Arginine Deiminase 1 Inhibitors journal July 2019
Exceptionally versatile – arginine in bacterial post-translational protein modifications journal November 2019
GnRH Stimulates Peptidylarginine Deiminase Catalyzed Histone Citrullination in Gonadotrope Cells journal September 2016
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis journal July 2015
Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer journal October 2017
Halogen Bonding Increases the Potency and Isozyme Selectivity of Protein Arginine Deiminase 1 Inhibitors journal September 2019
Structure, function, and inhibition of a genomic/clinical variant of Porphyromonas gingivalis peptidylarginine deiminase: Structure and Function of PPAD-T2 journal January 2019
An interplay of structure and intrinsic disorder in the functionality of peptidylarginine deiminases, a family of key autoimmunity-related enzymes journal July 2019
Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase. text January 2015
The Development of Benzimidazole-Based Clickable Probes for the Efficient Labeling of Cellular Protein Arginine Deiminases (PADs) journal January 2018
Molecular Interplay between the Dimer Interface and the Substrate-Binding Site of Human Peptidylarginine Deiminase 4 journal February 2017
Thioredoxin Modulates Protein Arginine Deiminase 4 (PAD4)-Catalyzed Citrullination journal February 2019

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