Containerless synthesis of amorphous and nanophase organic materials

Benmore, Chris J.; Weber, Johann R.

Containerless synthesis of amorphous and nanophase organic materials

Patent · 03 May 2016

OSTI ID:1250472

Benmore, Chris J.; Weber, Johann R.

The invention provides a method for producing a mixture of amorphous compounds, the method comprising supplying a solution containing the compounds; and allowing at least a portion of the solvent of the solution to evaporate while preventing the solute of the solution from contacting a nucleation point. Also provided is a method for transforming solids to amorphous material, the method comprising heating the solids in an environment to form a melt, wherein the environment contains no nucleation points; and cooling the melt in the environment.

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-06CH11357

Assignee:: UCHICAGO ARGONNE, LLC (Chicago, IL)

Patent Number(s):: 9,327,264

Application Number:: 13/361,164

OSTI ID:: 1250472

Country of Publication:: United States

Language:: English

References (10)

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Combined Synchrotron XRD/Raman Measurements: In Situ Identification of Polymorphic Transitions during Crystallization Processes Klimakow, Maria; Leiterer, Jork; Kneipp, Janina Langmuir, Vol. 26, Issue 13 https://doi.org/10.1021/la100540q	journal	July 2010
Two-dimensional detector software: From real detector to idealised image or two-theta scan Hammersley, A. P.; Svensson, S. O.; Hanfland, M. High Pressure Research, Vol. 14, Issue 4-6, p. 235-248 https://doi.org/10.1080/08957959608201408	journal	January 1996
Structure analysis using acoustically levitated droplets Leiterer, J.; Delißen, F.; Emmerling, F. Analytical and Bioanalytical Chemistry, Vol. 391, Issue 4 https://doi.org/10.1007/s00216-008-2011-2	journal	March 2008
Solidification of acoustically levitated o-terphenyl crystals: a Raman study Biswas, A. Journal of Crystal Growth, Vol. 147, Issue 1-2, p. 155-164 https://doi.org/10.1016/0022-0248(94)00670-9	journal	January 1995
Amorphization of Molecular Liquids of Pharmaceutical Drugs by Acoustic Levitation Benmore, C. J.; Weber, J. K. R. Physical Review X, Vol. 1, Issue 1 https://doi.org/10.1103/PhysRevX.1.011004	journal	August 2011
Acoustic levitator for structure measurements on low temperature liquid droplets Weber, J. K. R.; Rey, C. A.; Neuefeind, J. Review of Scientific Instruments, Vol. 80, Issue 8 https://doi.org/10.1063/1.3196177	journal	August 2009
Amorphous Pharmaceutical Solids: Characterization, Stabilization, and Development of Marketable Formulations of Poorly Soluble Drugs with Improved Oral Absorption Gao, Ping Molecular Pharmaceutics, Vol. 5, Issue 6 https://doi.org/10.1021/mp800203k	journal	November 2008
PDFgetX2: a GUI-driven program to obtain the pair distribution function from X-ray powder diffraction data Qiu, Xiangyun; Thompson, Jeroen W.; Billinge, Simon J. L. Journal of Applied Crystallography, Vol. 37, Issue 4, p. 678-678 https://doi.org/10.1107/S0021889804011744	journal	July 2004
Effect of Synthesis Techniques on Crystallite Size and Morphology of Lithium Aluminate Carrera, Luz Maria; Jimenez-Becerril, Jaime; Bosch, Pedro Journal of the American Ceramic Society, Vol. 78, Issue 4 https://doi.org/10.1111/j.1151-2916.1995.tb08417.x	journal	April 1995

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Containerless synthesis of amorphous and nanophase organic materials

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