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Title: DNA-cell conjugates

Abstract

The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.

Inventors:
; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1250470
Patent Number(s):
9,327,036
Application Number:
13/263,129
Assignee:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2010 Apr 08
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Hsiao, Shih-Chia, Francis, Matthew B., Bertozzi, Carolyn, Mathies, Richard, Chandra, Ravi, Douglas, Erik, Twite, Amy, Toriello, Nicholas, and Onoe, Hiroaki. DNA-cell conjugates. United States: N. p., 2016. Web.
Hsiao, Shih-Chia, Francis, Matthew B., Bertozzi, Carolyn, Mathies, Richard, Chandra, Ravi, Douglas, Erik, Twite, Amy, Toriello, Nicholas, & Onoe, Hiroaki. DNA-cell conjugates. United States.
Hsiao, Shih-Chia, Francis, Matthew B., Bertozzi, Carolyn, Mathies, Richard, Chandra, Ravi, Douglas, Erik, Twite, Amy, Toriello, Nicholas, and Onoe, Hiroaki. 2016. "DNA-cell conjugates". United States. https://www.osti.gov/servlets/purl/1250470.
@article{osti_1250470,
title = {DNA-cell conjugates},
author = {Hsiao, Shih-Chia and Francis, Matthew B. and Bertozzi, Carolyn and Mathies, Richard and Chandra, Ravi and Douglas, Erik and Twite, Amy and Toriello, Nicholas and Onoe, Hiroaki},
abstractNote = {The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.},
doi = {},
url = {https://www.osti.gov/biblio/1250470}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 03 00:00:00 EDT 2016},
month = {Tue May 03 00:00:00 EDT 2016}
}

Works referenced in this record:

Self-assembled cellular microarrays patterned using DNA barcodes
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Programmable Cell Adhesion Encoded by DNA Hybridization
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Viral Capsid DNA Aptamer Conjugates as Multivalent Cell-Targeting Vehicles
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DNA modification of live cell surface
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Recognition Imaging with a DNA Aptamer
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Behavior of synthetic polymers immobilized on a cell membrane
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Integrated microfluidic bioprocessor for single-cell gene expression analysis
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A Universal Method for the Preparation of Covalent Protein–DNA Conjugates for Use in Creating Protein Nanostructures
journal, November 2007


Self-assembling protein arrays on DNA chips by auto-labeling fusion proteins with a single DNA address
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Highly sensitive detectiong of DNA using enzyme-liked DNA-probe. I Colorimatric and fluorometric detection
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An enzymatic method for site-specific labeling of recombinant proteins with oligonucleotides
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Methods and systems for detecting and/or sorting targets
patent-application, January 2009