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Title: Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system

Journal Article · · BMC Structural Biology (Online)
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The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through the mycobacterial cell envelope to subvert the host immune response. Despite its important role in disease very little is known about the molecular architecture of the ESX-1 secretion system.

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS); Univ. of Kentucky, Lexington, KY (United States); Carnegie Inst. of Washington, Washington, DC (United States); Univ. of California, Los Angeles, CA (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES); US National Institutes of Health (NIH/NIGMS); USDOE Office of Science (SC), Biological and Environmental Research (BER)
Grant/Contract Number:
FC02-02ER63421; W-31-109-Eng-38; W-31-109-Eng-38.; 23616-002-06 F3:02; P30GM110787; P20GM103486
OSTI ID:
1618612
Alternate ID(s):
OSTI ID: 1249240; OSTI ID: 1364020; OSTI ID: 1466594
Journal Information:
BMC Structural Biology (Online), Journal Name: BMC Structural Biology (Online) Vol. 16 Journal Issue: 1; ISSN 1472-6807
Publisher:
Springer Science + Business MediaCopyright Statement
Country of Publication:
United Kingdom
Language:
English
Citation Metrics:
Cited by: 23 works
Citation information provided by
Web of Science

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Figures / Tables (6)

Fig. 1(p. 3)figure Fig. 1
Fig. 2(p. 4)figure Fig. 2
Fig. 3(p. 5)figure Fig. 3
Fig. 4(p. 6)figure Fig. 4
Fig. 5(p. 7)figure Fig. 5
Table 1(p. 8)table Table 1

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES
EccB
EccD
Mycobacterium tuberculosis
Type VII secretion system
ESX