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Title: Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications

Abstract

The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target within a sealed ceramic capsule with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g. chemical and or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc in a ceramic sublimation tube to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means.

Inventors:
;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1248479
Patent Number(s):
9,312,037
Application Number:
13/399,082
Assignee:
UCHICAGO ARGONNE, LLC (Chicago, IL) ANL
DOE Contract Number:  
AC02-06CH11357
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 Feb 17
Country of Publication:
United States
Language:
English
Subject:
07 ISOTOPE AND RADIATION SOURCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Ehst, David A., and Willit, James L.. Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications. United States: N. p., 2016. Web.
Ehst, David A., & Willit, James L.. Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications. United States.
Ehst, David A., and Willit, James L.. Tue . "Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications". United States. doi:. https://www.osti.gov/servlets/purl/1248479.
@article{osti_1248479,
title = {Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications},
author = {Ehst, David A. and Willit, James L.},
abstractNote = {The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target within a sealed ceramic capsule with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g. chemical and or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc in a ceramic sublimation tube to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Apr 12 00:00:00 EDT 2016},
month = {Tue Apr 12 00:00:00 EDT 2016}
}

Patent:

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Works referenced in this record:

Production of no-carrier added 67Cu
journal, January 1986

  • Mirzadeh, S.; Mausner, L. F.; Srivastava, S. C.
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 37, Issue 1, p. 29-36
  • DOI: 10.1016/0883-2889(86)90192-9

The production of copper 67 from natural zinc using a linear accelerator
journal, November 1970

  • Marceau, N.; Kruck, T. P. A.; McConnell, D. B.
  • The International Journal of Applied Radiation and Isotopes, Vol. 21, Issue 11, p. 667-669
  • DOI: 10.1016/0020-708X(70)90121-3