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Title: Anthrax carbohydrates, synthesis and uses thereof

Patent ·
OSTI ID:1246894
; ; ; ; ; ; ; ; ;

Research Organization:
Univ. of Georgia, Athens, GA (United States); The United States of America as Represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention, Washington, DC (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG09-93ER20097
Assignee:
University of Georgia Research Foundation, Inc. (Athens, GA) The United States of America as Represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention (Washington, DC)
Patent Number(s):
9,310,366
Application Number:
13/798,785
OSTI ID:
1246894
Resource Relation:
Patent File Date: 2013 Mar 13
Country of Publication:
United States
Language:
English

References (184)

Production and Validation of the Use of Gamma Phage for Identification of Bacillus anthracis journal September 2005
Synthesis of the β anomer of the spacer-equipped tetrasaccharide side chain of the major glycoprotein of the Bacillus anthracis exosporium journal December 2005
Studies towards a Conjugate Vaccine for Anthrax: Synthesis of the Tetrasaccharide Side Chain of theBacillus anthracis Exosporium journal June 2006
Serotype-converting bacteriophages and O-antigen modification in Shigella flexneri journal January 2000
Probing the Specificity of Aminoglycoside−Ribosomal RNA Interactions with Designed Synthetic Analogs journal March 1998
Isolation and Characterization of Structural Components of Bacillus cereus AHU 1356 Cell Walls journal May 1977
Fatal Pneumonia among Metalworkers Due to Inhalation Exposure to Bacillus cereus Containing Bacillus anthracis Toxin Genes journal February 2007
Bacillus anthracis, a story of nature subverted by man journal September 2005
Multilocus sequence typing reveals that Bacillus cereus strains isolated from clinical infections have distinct phylogenetic origins journal April 2005
Synthesis and characterization of gentiobiose heptaacetate conjugate vaccines that produce endotoxin-neutralizing antibodies journal November 1990
Teichoic Acid Is an Essential Polymer in Bacillus subtilis That Is Functionally Distinct from Teichuronic Acid journal November 2004
Single strand conformation polymorphism analysis of PCR-tDNA fingerprinting to address the identification of Bacillus species journal December 1997
Potential biological targets of Bacillus anthracis in anti-infective approaches against the threat of bioterrorism journal August 2007
Conformational analysis of nitrilium intermediates in glycosylation reactions journal August 1993
The Immunogenicity of the Tumor-Associated Antigen Lewisy May Be Suppressed by a Bifunctional Cross-Linker Required for Coupling to a Carrier Protein journal July 2004
Conjugation of yeast mannans with protein employing cyanopyridinium agent (CDAP) – an effective route of antifungal vaccine preparation journal January 2000
Structures of the oligosaccharides obtained from the core regions of the lipopolysaccharides of Bradyhizobium japonicum 61A101c and its symbiotically defective lipopolysaccharide mutant, JS314 journal July 1992
Strain discrimination among B. anthracis and related organisms by characterization of bclA polymorphisms using PCR coupled with agarose gel or microchannel fluidics electrophoresis journal January 2006
Rapid discrimination of Bacillus anthracis from other members of the B. cereus group by mass and sequence of “intact” small acid soluble proteins (SASPs) using mass spectrometry journal November 2006
Bacillus cereus strains fall into two clusters (one closely and one more distantly related) to Bacillus anthracis according to amino acid substitutions in small acid-soluble proteins as determined by tandem mass spectrometry journal June 2007
Construction and characterization of a protective antigen-deficient Bacillus anthracis strain journal July 1990
Anthrax capsule vaccine protects against experimental infection? journal November 2004
The structure of the lipopolysaccharide from a galU mutant of Pseudomonas aeruginosa serogroup-O11 journal December 2005
A simple and rapid method for the permethylation of carbohydrates journal August 1984
Synthesis of an artificial antigen that corresponds to a disaccharide repeating unit of the capsular polysaccharide of Haemophilus influenzae type d. A facile synthesis of methyl 2-acetamido-2-deoxy-β-d-mannopyranoside journal September 1992
Antibacterial Activities and Characterization of Novel Inhibitors of LpxC journal June 2002
Synthesis of the Antigenic Tetrasaccharide Side Chain from the Major Glycoprotein of Bacillus anthracis Exosporium journal August 2007
The atxA gene product activates transcription of the anthrax toxin genes and is essential for virulence journal June 1995
Novel Oligosaccharide Side Chains of the Collagen-like Region of BclA, the Major Glycoprotein of the Bacillus anthracis Exosporium journal May 2004
A mild procedure for the regiospecific benzylation and allylation of polyhydroxy-compounds via their stannylene derivatives in non-polar solvents journal January 1981
Two-Component Direct Fluorescent-Antibody Assay for Rapid Identification of Bacillus anthracis journal October 2002
Presence of flagellar antigenic subfactors in serotype 3 of Bacillus thuringiensis journal January 1970
Proteomic Profiling and Identification of Immunodominant Spore Antigens of Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis journal September 2006
The US Capitol Bioterrorism Anthrax Exposures: Clinical Epidemiological and Immunological Characteristics journal January 2007
atxA Controls Bacillus anthracis Capsule Synthesis via acpA and a Newly Discovered Regulator, acpB journal December 2003
Anthrax toxins journal October 1999
Isolation and purification of cell wall polysaccharide of Bacillus anthracis (Δ Sterne) journal August 1991
Application of the Synthetic Aminosugars for Glycodiversification:  Synthesis and Antimicrobial Studies of Pyranmycin journal March 2004
Oligosaccharide microarrays to decipher the glyco code journal July 2004
Structural Characterization of the O-antigenic Polysaccharide of the Lipopolysaccharide from Rhizobium etli Strain CE3 : A UNIQUE journal April 2000
Bacillus anthracis Cell Envelope Components book January 2002
Carbohydrates and glycoproteins of Bacillus anthracis and related bacilli: targets for biodetection journal August 2003
Poly(glucosyl-N-acetylgalactosamine 1-phosphate), a wall teichoic acid of Bacillus subtilis 168: its biosynthetic pathway and mode of attachment to peptidoglycan journal June 2006
Anthrax Vaccine: Evidence for Safety and Efficacy Against Inhalational Anthrax journal December 1999
Rational Design of Benzyl-Type Protecting Groups Allows Sequential Deprotection of Hydroxyl Groups by Catalytic Hydrogenolysis journal June 1998
In Vitro Reconstitution of Two Essential Steps in Wall Teichoic Acid Biosynthesis journal January 2006
Recent advances in the construction of β-D-mannose and β-D-mannosamine linkages journal January 2000
Structural Characterization of the Lipid A Component of Sinorhizobium sp. NGR234 Rough and Smooth Form Lipopolysaccharide : DEMONSTRATION THAT THE DISTAL AMIDE-LINKED ACYLOXYACYL RESIDUE CONTAINING THE LONG CHAIN FATTY ACID IS CONSERVED IN journal November 2002
The Neisseria meningitidis Serogroup A Capsular Polysaccharide O-3 and O-4 Acetyltransferase journal August 2004
Protein-Polysaccharide Conjugation book January 2001
De Novo Asymmetric Synthesis of the Anthrax Tetrasaccharide by a Palladium-Catalyzed Glycosylation Reaction journal July 2007
De Novo Asymmetric Synthesis of the Anthrax Tetrasaccharide by a Palladium-Catalyzed Glycosylation Reaction journal July 2007
The synthesis of some 4-substituted derivatives of 1,2,3-tri-O-acetyl-6-deoxy L-glucopyranose having cytotoxic activity journal July 1979
The Occurrence of α(1 → 2) Linked N -Acetylperosamine-Homopolymer in Lipopolysaccharides of Non-O1 Vibrio cholerae Possessing an Antigenic Factor in Common with Ol V. cholerae journal December 1990
Genetic Diversity of Bacillus cereus / B. thuringiensis Isolates from Natural Sources journal August 1998
Multilocus Sequence Typing Scheme for Bacteria of the Bacillus cereus Group journal January 2004
Overview: cause and prevention in biowarfare and bioterrorism journal August 2002
Identification of anthrax toxin genes in a Bacillus cereus associated with an illness resembling inhalation anthrax journal May 2004
Genetic diversity of clinical isolates of Bacillus cereus using multilocus sequence typing journal January 2008
Serological Cross-Reaction between Intact and Chemically Modified Lipopolysaccharides of O1 Vibrio cholerae Inaba and Non-O1 V. cholerae Bio-Serogroup Hakata journal November 1992
Structural studies on the neutral polysaccharide of Bacillus subtilis AHU 1219 cell walls journal January 1989
Why are proteins O-glycosylated? journal August 1990
Bioterrorism-Related Inhalational Anthrax: The First 10 Cases Reported in the United States journal December 2001
Investigation of Bioterrorism-Related Anthrax, United States, 2001: Epidemiologic Findings journal October 2002
Expanding the Pyrimidine Diphosphosugar Repertoire: The Chemoenzymatic Synthesis of Amino- and Acetamidoglucopyranosyl Derivatives journal April 2001
Glycosyltransferase assays utilizing N-acetyllactosamine acceptor immobilized on a cellulose membrane journal December 2003
O -Acetylation of the Terminal N -Acetylglucosamine of the Lipooligosaccharide Inner Core in Neisseria meningitidis : INFLUENCE ON INNER CORE STRUCTURE AND ASSEMBLY journal May 2006
Cloning and Characterization of Novel Ficolins from the Solitary Ascidian, Halocynthia roretzi journal March 2001
BslA, a pXO1-encoded adhesin of Bacillus anthracis journal March 2008
Bacillus anthracis Surface-Layer Proteins Assemble by Binding to the Secondary Cell Wall Polysaccharide in a Manner that Requires csaB and tagO journal September 2010
Genetic relationships of Bacillus anthracis and closely related species based on variable-number tandem repeat analysis and BOX-PCR genomic fingerprinting journal January 2002
A General Strategy for Stereoselective Glycosylations journal August 2005
Stereoselective Glycosylation Reactions with Chiral Auxiliaries journal January 2005
Characterization of Bacillus anthracis-Like Bacteria Isolated from Wild Great Apes from Cote d'Ivoire and Cameroon journal July 2006
Structural studies on the acidic polysaccharide of Bacillus cereus AHU 1356 cell walls journal May 1985
Population Structure of the Bacillus cereus Group as Determined by Sequence Analysis of Six Housekeeping Genes and the plcR Gene journal August 2004
Saccharides cross-reactive with Bacillus anthracis spore glycoprotein as an anthrax vaccine component journal June 2008
Decontamination of Bacterial Spores by a Microwave Plasma Torch conference June 2005
Perimycin: Chemistry of perosamine journal January 1966
A New Bacillus anthracis Found in Wild Chimpanzees and a Gorilla from West and Central Africa journal January 2006
Activation of soluble polysaccharides with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate for use in protein—polysaccharide conjugate vaccines and immunological reagents journal February 1996
Cell Wall Carbohydrate Compositions of Strains from the Bacillus cereus Group of Species Correlate with Phylogenetic Relatedness journal November 2007
Structural Elucidation of the Nonclassical Secondary Cell Wall Polysaccharide from Bacillus cereus ATCC 10987 : COMPARISON WITH THE POLYSACCHARIDES FROM BACILLUS ANTHRACIS AND B. CEREUS TYPE STRAIN ATCC 14579 REVEALS BOTH UNIQUE AND COMMON STRUCTURAL FEATURES journal August 2008
Secondary cell wall polysaccharides of Bacillus anthracis are antigens that contain specific epitopes which cross-react with three pathogenic Bacillus cereus strains that caused severe disease, and other epitopes common to all the Bacillus cereus strains tested journal March 2009
Structural Characterization of a K-antigen Capsular Polysaccharide Essential for Normal Symbiotic Infection in Rhizobium sp. NGR234 : DELETION OF THE rkpMNO LOCUS PREVENTS SYNTHESIS OF 5,7-DIACETAMIDO-3,5,7,9-TETRADEOXY-NON-2-ULOSONIC ACID journal June 2006
Glycoprotein conjugate vaccines journal October 1999
Synthesis of (25R)-ruscogenin-1-yl β-d-xylopyranosyl-(1→3)-[β-d-glucopyranosyl-(1→2)]-β-d-fucopyranoside journal December 2000
Molecular recognition specificity of Bacillus anthracis spore antibodies journal August 1999
Murine Model of Pulmonary Anthrax: Kinetics of Dissemination, Histopathology, and Mouse Strain Susceptibility journal July 2004
Drug Targeting Mycobacterium tuberculosis Cell Wall Synthesis: Genetics of dTDP-Rhamnose Synthetic Enzymes and Development of a Microtiter Plate-Based Screen for Inhibitors of Conversion of dTDP-Glucose to dTDP-Rhamnose journal May 2001
Human Neutrophils Kill Bacillus anthracis journal January 2005
Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity journal June 2002
Synthesis and Antigenic Analysis of the BclA Glycoprotein Oligosaccharide from the Bacillus anthracis Exosporium journal December 2006
Fluorescent Heteroduplex Assay for Monitoring Bacillus anthracis and Close Relatives in Environmental Samples journal June 2003
Bacterial SLH domain proteins are non-covalently anchored to the cell surface via a conserved mechanism involving wall polysaccharide pyruvylation journal September 2000
Conjugation of meningococcal lipooligosaccharides through their lipid A terminus conserves their inner epitopes and results in conjugate vaccines having improved immunological properties journal January 2003
Synthesis of the Tetrasaccharide Repeating Unit of the Antigen from Escherichia coli O126 as Its Methyl Glycoside journal September 1998
Anthrax journal October 2001
Enhancement of Anthrax Lethal Toxin Cytotoxicity: a Subset of Monoclonal Antibodies against Protective Antigen Increases Lethal Toxin-Mediated Killing of Murine Macrophages journal May 2004
A High-Affinity Monoclonal Antibody to Anthrax Protective Antigen Passively Protects Rabbits before and after Aerosolized Bacillus anthracis Spore Challenge journal January 2005
Reactivity-based one-pot total synthesis of fucose GM1 oligosaccharide: A sialylated antigenic epitope of small-cell lung cancer journal January 2003
The Role of Bacterial Polysaccharide Capsules as Virulence Factors book January 1990
Biosynthesis of the wall neutral polysaccharide in Bacillus cereus AHU 1356 journal November 1986
Synthesis of a Hexasaccharide Repeating Unit from Bacillus anthracis Vegetative Cell Walls journal March 2008
Molecular Analysis of Carbohydrate−Antibody Interactions: Case Study Using a Bacillus anthracis Tetrasaccharide journal August 2010
Structures of two O-polysaccharides of the lipopolysaccharide of Citrobacter youngae PCM 1538 (serogroup O9) journal March 2004
Application of carbohydrate microarray technology for the detection of Burkholderia pseudomallei, Bacillus anthracis and Francisella tularensis antibodies journal November 2008
Synthesis and conformational analysis of methyl 2-O-(α-D-Mannopyranosyl)-α-D-mannopyranoside journal February 1991
In vitro correlate of immunity in a rabbit model of inhalational anthrax journal September 2001
Synthesis of Glycoconjugate Vaccines against Shigella dysenteriae Type 1 journal August 1998
Bacillus subtilis and Other Gram-Positive Bacteria book April 1993
Improvements in the Regioselectivity of Alkylation Reactions of Stannylene Acetals journal January 1996
Specific, Sensitive, and Quantitative Enzyme-Linked Immunosorbent Assay for Human Immunoglobulin G Antibodies to Anthrax Toxin Protective Antigen journal October 2002
Genome Differences That Distinguish Bacillus anthracis from Bacillus cereus and Bacillus thuringiensis journal May 2003
The structure of the lipooligosaccharide (LOS) from the  -1,2-N-acetyl glucosamine transferase (rfaKNMB) mutant strain CMK1 of Neisseria meningitidis: implications for LOS inner core assembly and LOS-based vaccines journal August 2001
The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1 journal February 2004
Genomics of the Bacillus cereus group of organisms journal April 2005
Generation of α-D-glucopyranosylacetonitrilium ions. Concerning the reverse anomeric effect journal January 1990
The PA14 domain, a conserved all-β domain in bacterial toxins, enzymes, adhesins and signaling molecules journal July 2004
Antibody Responses to a Spore Carbohydrate Antigen as a Marker of Nonfatal Inhalation Anthrax in Rhesus Macaques journal March 2011
A selective ring opening reaction of 4,6-O-benzylidene acetals in carbohydrates using trialkylsilane derivatives journal July 2000
Studies toward a conjugate vaccine for anthrax. Synthesis and characterization of anthrose [4,6-dideoxy-4-(3-hydroxy-3-methylbutanamido)-2-O-methyl-d-glucopyranose] and its methyl glycosides journal July 2005
Synthesis of the tetrasaccharide side chain of the major glycoprotein of the Bacillus anthracis exosporium journal February 2006
Immunogens related to the synthetic tetrasaccharide side chain of the Bacillus anthracis exosporium journal June 2007
Structure of Teichoic- Acid-Glycopeptide Complexes from Cell Walls of Bacillus cereus AHU 1030 journal April 1983
The diacetamidodideoxyuronic-acid-containing glycan chain of Bacillus stearothermophilus NRS 2004/3a represents the secondary cell-wall polymer of wild-type B. stearothermophilus strains journal July 1999
A pyrophosphate bridge links the pyruvate-containing secondary cell wall polymer of Paenibacillus alvei CCM 2051 to muramic acid journal January 2000
The structure of secondary cell wall polymers: how Gram-positive bacteria stick their cell walls together journal March 2005
New Methods for the Synthesis of Glycosides and Oligosaccharides—Are There Alternatives to the Koenigs-Knorr Method? [New Synthetic Methods (56)] journal March 1986
Sweet new world: glycoproteins in bacterial pathogens journal December 2003
Poly(γ-d-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: A potential addition to the anthrax vaccine journal July 2003
A bacteriolytic agent that detects and kills Bacillus anthracis journal August 2002
Synthesis and medical applications of oligosaccharides journal April 2007
Activation of soluble polysaccharides with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP) for use in protein-polysaccharide conjugate vaccines and immunological reagents. II. Selective crosslinking of proteins to CDAP-activated polysaccharides journal January 2000
Preventive and Therapeutic Effects of α1-Acid Glycoprotein in Mice Infected with B. anthracis journal October 2005
Fucosyltransferase-catalyzed formation of l-galactosylated Lewis structures journal December 1997
Identification of the Immunodominant Protein and Other Proteins of the Bacillus anthracis Exosporium journal March 2003
The secondary cell wall polymer of Geobacillus tepidamans GS5-97T: structure of different glycoforms journal October 2005
An avidin-biotin based ELISA for quantitation of antibody to bacterial polysaccharides journal January 1985
Monoclonal Antibodies for Bacillus anthracis Spore Detection and Functional Analyses of Spore Germination and Outgrowth journal May 2006
A collagen-like surface glycoprotein is a structural component of the Bacillus anthracis exosporium journal July 2002
Anti-Carbohydrate Antibodies for the Detection of Anthrax Spores journal October 2006
Immuno-detection of anthrose containing tetrasaccharide in the exosporium of Bacillus anthracis and Bacillus cereus strains journal May 2009
Efficient Stereoselective Synthesis of γ- N -Glycosyl Asparagines by N-Glycosylation of Primary Amide Groups journal February 2005
Differential immune responses to α-gal epitopes on xenografts and allografts: implications for accommodation in xenotransplantation journal February 2000
Fluorescent Amplified Fragment Length Polymorphism Analysis of Norwegian Bacillus cereus and Bacillus thuringiensis Soil Isolates journal October 2001
Efficient growth inhibition of Bacillus anthracis by knocking out the ribonucleotide reductase tyrosyl radical journal December 2005
Anthrax vaccines: past, present and future journal August 1991
The MisR/MisS Two-component Regulatory System Influences Inner Core Structure and Immunotype of Lipooligosaccharide in Neisseria meningitidis journal June 2004
Strain-Specific Single-Nucleotide Polymorphism Assays for the Bacillus anthracis Ames Strain journal November 2006
Synthesis of β-O-glycosides using enol ether and imidate derived leaving groups. Emphasis on the use of nitriles as a solvent journal January 1991
Chemical Synthesis and Immunological Properties of Oligosaccharides Derived from the Vegetative Cell Wall of Bacillus anthracis journal July 2008
Iodonium ion promoted reactions at the anomeric centre. II An efficient thioglycoside mediated approach toward the formation of 1,2-trans linked glycosides and glycosidic esters journal January 1990
Disaccharide Mimetics of the Aminoglycoside Antibiotic Neamine journal September 2004
Activity of α- and θ-Defensins against Primary Isolates of HIV-1 journal June 2004
Anthrax vaccine design: strategies to achieve comprehensive protection against spore, bacillus, and toxin journal March 2005
Photogenerated glycan arrays identify immunogenic sugar moieties ofBacillus anthracis exosporium journal January 2007
A convergent strategy for the preparation of N-glycan core di-, tri-, and pentasaccharide thioaldoses for the site-specific glycosylation of peptides and proteins bearing free cysteines journal January 2004
A silent bomb: The risk of anthrax as a weapon of mass destruction journal April 2003
Immunology of bacterial polysaccharide antigens journal November 2003
Total Synthesis of AntigenBacillus Anthracis Tetrasaccharide—Creation of an Anthrax Vaccine Candidate journal October 2005
A Chemically Synthesized Version of the Insect Antibacterial Glycopeptide, Diptericin, Disrupts Bacterial Membrane Integrity † journal September 1999
Enzyme-catalyzed synthesis of N-acetyllactosamine with in situ regeneration of uridine 5'-diphosphate glucose and uridine 5'-diphosphate galactose journal December 1982
Use of 1,2-dichloro 4,5-dicyanoquinone (DDQ) for cleavage of the 2-naphthylmethyl (NAP) group journal January 2000
Glycosyl trifluoroacetimidates. Part 1: Preparation and application as new glycosyl donors journal March 2001
Glycosyl Trifluoroacetimidates. 2. Synthesis of Dioscin and Xiebai Saponin I journal December 2002
Synthesis of oligosaccharides, reagents and methods related thereto patent November 2001
Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries patent July 2002
Modified polysaccharide adjuvant-protein antigen conjugates, the preparation thereof and the use thereof patent June 2003
Linkers for synthesis of oligosaccharides on solid supports patent June 2003
Targeting antigens to the MHC class I processing pathway with an anthrax toxin fusion protein patent July 2003
Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries patent February 2004
Assays for detection of Bacillus anthracis patent December 2004
Solid- and solution-phase synthesis of heparin and other glycosaminoglycans patent January 2005
Monoclonal antibodies specific for anthrax and peptides derived from the antibodies thereof patent July 2005
Antibodies with increased affinities for anthrax antigens patent July 2005
Targeting antigens to the MHC class I processing pathway with an anthrax toxin fusion protein patent August 2006
Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries patent September 2006
Apparatus and methods for the automated synthesis of oligosaccharides patent January 2007
Synthesis of oligosaccharides, reagents and methods related thereto patent May 2007
High level constitutive production of anthrax protective antigen patent February 2008
Assays for detection of Bacillus anthracis patent February 2008
Recombinant antibodies for the detection and neutralization of anthrax toxin patent November 2008
Anthrax carbohydrates, synthesis and uses thereof patent April 2013

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