Structural and Functional Analysis of Surface Proteins from an A(H3N8) Influenza Virus Isolated from New England Harbor Seals

Yang, Hua; Nguyen, Ha T.; Carney, Paul J.; Guo, Zhu; Chang, Jessie C.; Jones, Joyce; Davis, Charles T.; Villanueva, Julie M.; Gubareva, Larisa V.; Stevens, James

doi:10.1128/JVI.02723-14

Title: Structural and Functional Analysis of Surface Proteins from an A(H3N8) Influenza Virus Isolated from New England Harbor Seals

Journal Article · Thu Feb 05 00:00:00 EST 2015 · Journal of Virology

DOI:https://doi.org/10.1128/JVI.02723-14· OSTI ID:1245870

Yang, Hua ^[1]; Nguyen, Ha T. ^[2]; Carney, Paul J. ^[1]; Guo, Zhu ^[1]; Chang, Jessie C. ^[1]; Jones, Joyce ^[1]; Davis, Charles T. ^[1]; Villanueva, Julie M. ^[1]; Gubareva, Larisa V. ^[1]; Stevens, James ^[1]

Centers for Disease Control and Prevention, Atlanta, GA (United States)
Centers for Disease Control and Prevention, Atlanta, GA (United States); Battelle Memorial Inst., Atlanta, GA (United States)

In late 2011, an A(H3N8) influenza virus infection resulted in the deaths of 162 New England harbor seals. Virus sequence analysis and virus receptor binding studies highlighted potential markers responsible for mammalian adaptation and a mixed receptor binding preference. Here, we present a detailed structural and biochemical analysis of the surface antigens of the virus. Results obtained with recombinant proteins for both the hemagglutinin and neuraminidase indicate a true avian receptor binding preference. Although the detection of this virus in new species highlights an increased potential for cross-species transmission, our results indicate that the A(H3N8) virus currently poses a low risk to humans. Cross-species transmission of zoonotic influenza viruses increases public health concerns. Here, we report a molecular and structural study of the major surface proteins from an A(H3N8) influenza virus isolated from New England harbor seals. Furthermore, the results improve our understanding of these viruses as they evolve and provide important information to aid ongoing risk assessment analyses as these zoonotic influenza viruses continue to circulate and adapt to new hosts.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); Center for Disease Control and Prevention; USDOE Office of Science (SC), Biological and Environmental Research (BER); National Inst. of Health; National Inst. of General Medical Sciences

Grant/Contract Number:: AC02-06CH11357; P41GM103393; GM62116

OSTI ID:: 1245870

Journal Information:: Journal of Virology, Vol. 89, Issue 5; ISSN 0022-538X

Publisher:: American Society for MicrobiologyCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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Cited by: 12 works

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