Identification of genetic factors that modify motor performance and body weight using Collaborative Cross mice

Mao, Jian -Hua; Langley, Sasha A.; Huang, Yurong; Hang, Michael; Bouchard, Kristofer E.; Celniker, Susan E.; Brown, James B.; Jansson, Janet K.; Karpen, Gary H.; Snijders, Antoine M.

doi:10.1038/srep16247

Title: Identification of genetic factors that modify motor performance and body weight using Collaborative Cross mice

Journal Article · Mon Nov 09 00:00:00 EST 2015 · Scientific Reports

DOI:https://doi.org/10.1038/srep16247· OSTI ID:1243256

Mao, Jian -Hua ^[1]; Langley, Sasha A. ^[1]; Huang, Yurong ^[1]; Hang, Michael ^[1]; Bouchard, Kristofer E. ^[1]; Celniker, Susan E. ^[1]; Brown, James B. ^[1]; Jansson, Janet K. ^[2]; Karpen, Gary H. ^[3]; Snijders, Antoine M. ^[1]

Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Berkeley, CA (United States)

Evidence has emerged that suggests a link between motor deficits, obesity and many neurological disorders. However, the contributing genetic risk factors are poorly understood. Here we used the Collaborative Cross (CC), a large panel of newly inbred mice that captures 90% of the known variation among laboratory mice, to identify the genetic loci controlling rotarod performance and its relationship with body weight in a cohort of 365 mice across 16 CC strains. Body weight and rotarod performance varied widely across CC strains and were significantly negatively correlated. Genetic linkage analysis identified 14 loci that were associated with body weight. However, 45 loci affected rotarod performance, seven of which were also associated with body weight, suggesting a strong link at the genetic level. Lastly, we show that genes identified in this study overlap significantly with those related to neurological disorders and obesity found in human GWA studies. In conclusion, our results provide a genetic framework for studies of the connection between body weight, the central nervous system and behavior.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC05-76RL01830; AC02-05CH11231

OSTI ID:: 1243256

Alternate ID(s):: OSTI ID: 1378638

Report Number(s):: PNNL-SA-115429

Journal Information:: Scientific Reports, Vol. 5; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 40 works

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