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Title: Systems and methods for selective detection and imaging in coherent Raman microscopy by spectral excitation shaping

Abstract

A microscopy imaging system is disclosed that includes a light source system, a spectral shaper, a modulator system, an optics system, an optical detector and a processor. The light source system is for providing a first train of pulses and a second train of pulses. The spectral shaper is for spectrally modifying an optical property of at least some frequency components of the broadband range of frequency components such that the broadband range of frequency components is shaped producing a shaped first train of pulses to specifically probe a spectral feature of interest from a sample, and to reduce information from features that are not of interest from the sample. The modulator system is for modulating a property of at least one of the shaped first train of pulses and the second train of pulses at a modulation frequency. The optical detector is for detecting an integrated intensity of substantially all optical frequency components of a train of pulses of interest transmitted or reflected through the common focal volume. The processor is for detecting a modulation at the modulation frequency of the integrated intensity of substantially all of the optical frequency components of the train of pulses of interest duemore » to the non-linear interaction of the shaped first train of pulses with the second train of pulses as modulated in the common focal volume, and for providing an output signal for a pixel of an image for the microscopy imaging system.« less

Inventors:
; ;
Publication Date:
Research Org.:
President and Fellows Harvard College, Cambridge, MA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1243043
Patent Number(s):
9,285,575
Application Number:
12/690,579
Assignee:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, MA) CHO
DOE Contract Number:  
FG02-07ER15875
Resource Type:
Patent
Resource Relation:
Patent File Date: 2010 Jan 20
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Xie, Xiaoliang Sunney, Freudiger, Christian, and Min, Wei. Systems and methods for selective detection and imaging in coherent Raman microscopy by spectral excitation shaping. United States: N. p., 2016. Web.
Xie, Xiaoliang Sunney, Freudiger, Christian, & Min, Wei. Systems and methods for selective detection and imaging in coherent Raman microscopy by spectral excitation shaping. United States.
Xie, Xiaoliang Sunney, Freudiger, Christian, and Min, Wei. Tue . "Systems and methods for selective detection and imaging in coherent Raman microscopy by spectral excitation shaping". United States. https://www.osti.gov/servlets/purl/1243043.
@article{osti_1243043,
title = {Systems and methods for selective detection and imaging in coherent Raman microscopy by spectral excitation shaping},
author = {Xie, Xiaoliang Sunney and Freudiger, Christian and Min, Wei},
abstractNote = {A microscopy imaging system is disclosed that includes a light source system, a spectral shaper, a modulator system, an optics system, an optical detector and a processor. The light source system is for providing a first train of pulses and a second train of pulses. The spectral shaper is for spectrally modifying an optical property of at least some frequency components of the broadband range of frequency components such that the broadband range of frequency components is shaped producing a shaped first train of pulses to specifically probe a spectral feature of interest from a sample, and to reduce information from features that are not of interest from the sample. The modulator system is for modulating a property of at least one of the shaped first train of pulses and the second train of pulses at a modulation frequency. The optical detector is for detecting an integrated intensity of substantially all optical frequency components of a train of pulses of interest transmitted or reflected through the common focal volume. The processor is for detecting a modulation at the modulation frequency of the integrated intensity of substantially all of the optical frequency components of the train of pulses of interest due to the non-linear interaction of the shaped first train of pulses with the second train of pulses as modulated in the common focal volume, and for providing an output signal for a pixel of an image for the microscopy imaging system.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 15 00:00:00 EDT 2016},
month = {Tue Mar 15 00:00:00 EDT 2016}
}

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