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Title: Dried plum diet protects from bone loss caused by ionizing radiation

Abstract

Bone loss caused by ionizing radiation is a potential health concern for radiotherapy patients, radiation workers and astronauts. In animal studies, exposure to ionizing radiation increases oxidative damage in skeletal tissues, and results in an imbalance in bone remodeling initiated by increased bone-resorbing osteoclasts. Therefore, we evaluated various candidate interventions with antioxidant or antiinflammatory activities (antioxidant cocktail, dihydrolipoic acid, ibuprofen, dried plum) both for their ability to blunt the expression of resorption-related genes in marrow cells after irradiation with either gamma rays (photons, 2 Gy) or simulated space radiation (protons and heavy ions, 1 Gy) and to prevent bone loss. Dried plum was most effective in reducing the expression of genes related to bone resorption (Nfe2l2, Rankl, Mcp1, Opg, TNF-α) and also preventing later cancellous bone decrements caused by irradiation with either photons or heavy ions. Furthermore, dietary supplementation with DP may prevent the skeletal effects of radiation exposures either in space or on Earth.

Authors:
 [1];  [1];  [1];  [1];  [1];  [1];  [2];  [3];  [4];  [1]
  1. NASA Ames Research Center, Moffett Field, CA (United States)
  2. Univ. of California, Irvine, CA (United States)
  3. Texas A & M Univ., College Station, TX (United States)
  4. Univ. of California, San Francisco, CA (United States)
Publication Date:
Research Org.:
NASA Ames Research Center (ARC), Moffett Field, Mountain View, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
OSTI Identifier:
1242248
Grant/Contract Number:  
SC0001507
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Scientific Reports
Additional Journal Information:
Journal Volume: 6; Journal ID: ISSN 2045-2322
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; bone; targeted bone remodelling; osteoimmunology; radiotherapy

Citation Formats

Schreurs, A. -S., Shirazi-Fard, Y., Shahnazari, M., Alwood, J. S., Truong, T. A., Tahimic, C. G. T., Limoli, C. L., Turner, N. D., Halloran, B., and Globus, R. K. Dried plum diet protects from bone loss caused by ionizing radiation. United States: N. p., 2016. Web. doi:10.1038/srep21343.
Schreurs, A. -S., Shirazi-Fard, Y., Shahnazari, M., Alwood, J. S., Truong, T. A., Tahimic, C. G. T., Limoli, C. L., Turner, N. D., Halloran, B., & Globus, R. K. Dried plum diet protects from bone loss caused by ionizing radiation. United States. https://doi.org/10.1038/srep21343
Schreurs, A. -S., Shirazi-Fard, Y., Shahnazari, M., Alwood, J. S., Truong, T. A., Tahimic, C. G. T., Limoli, C. L., Turner, N. D., Halloran, B., and Globus, R. K. 2016. "Dried plum diet protects from bone loss caused by ionizing radiation". United States. https://doi.org/10.1038/srep21343. https://www.osti.gov/servlets/purl/1242248.
@article{osti_1242248,
title = {Dried plum diet protects from bone loss caused by ionizing radiation},
author = {Schreurs, A. -S. and Shirazi-Fard, Y. and Shahnazari, M. and Alwood, J. S. and Truong, T. A. and Tahimic, C. G. T. and Limoli, C. L. and Turner, N. D. and Halloran, B. and Globus, R. K.},
abstractNote = {Bone loss caused by ionizing radiation is a potential health concern for radiotherapy patients, radiation workers and astronauts. In animal studies, exposure to ionizing radiation increases oxidative damage in skeletal tissues, and results in an imbalance in bone remodeling initiated by increased bone-resorbing osteoclasts. Therefore, we evaluated various candidate interventions with antioxidant or antiinflammatory activities (antioxidant cocktail, dihydrolipoic acid, ibuprofen, dried plum) both for their ability to blunt the expression of resorption-related genes in marrow cells after irradiation with either gamma rays (photons, 2 Gy) or simulated space radiation (protons and heavy ions, 1 Gy) and to prevent bone loss. Dried plum was most effective in reducing the expression of genes related to bone resorption (Nfe2l2, Rankl, Mcp1, Opg, TNF-α) and also preventing later cancellous bone decrements caused by irradiation with either photons or heavy ions. Furthermore, dietary supplementation with DP may prevent the skeletal effects of radiation exposures either in space or on Earth.},
doi = {10.1038/srep21343},
url = {https://www.osti.gov/biblio/1242248}, journal = {Scientific Reports},
issn = {2045-2322},
number = ,
volume = 6,
place = {United States},
year = {Thu Feb 11 00:00:00 EST 2016},
month = {Thu Feb 11 00:00:00 EST 2016}
}

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Cited by: 40 works
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Works referenced in this record:

Dried plum polyphenols attenuate the detrimental effects of TNF-α on osteoblast function coincident with up-regulation of Runx2, Osterix and IGF-I
journal, January 2009


The Influence of Therapeutic Radiation on the Patterns of Bone Marrow in Ovary-Intact and Ovariectomized Mice
journal, August 2012


Spaceflight-induced Bone Loss: Is there an Osteoporosis Risk?
journal, April 2013


Fruits and dietary phytochemicals in bone protection
journal, December 2012


Antioxidant Diet Supplementation Starting 24 Hours after Exposure Reduces Radiation Lethality
journal, April 2010


Mechanical loading causes site-specific anabolic effects on bone following exposure to ionizing radiation
journal, December 2015


The combined effects of reduced weightbearing and ionizing radiation on splenic lymphocyte population and function
journal, July 2011


Effects of Dried Plum Supplementation on Bone Metabolism in Adult C57BL/6 Male Mice
journal, December 2013


Bisphosphonates in the treatment of patients with lung cancer and metastatic bone disease: a systematic review and meta-analysis
journal, September 2012


Dried Plum’s Unique Capacity to Reverse Bone Loss and Alter Bone Metabolism in Postmenopausal Osteoporosis Model
journal, March 2013


Dried Fruits: Excellent in Vitro and in Vivo Antioxidants
journal, February 2005


Trabecular bone architecture in the pathogenesis and prevention of fracture
journal, January 1987


Rabbiteye blueberry prevents osteoporosis in ovariectomized rats
journal, August 2014


Combining Fructooligosaccharide and Dried Plum Has the Greatest Effect on Restoring Bone Mineral Density Among Select Functional Foods and Bioactive Compounds
journal, April 2010


Chemotherapy- and Irradiation-Induced Bone Loss in Adults with Solid Tumors
journal, February 2015


Ionizing Radiation Stimulates Expression of Pro-Osteoclastogenic Genes in Marrow and Skeletal Tissue
journal, June 2015


Combining Fructooligosaccharide and Dried Plum Has the Greatest Effect on Restoring Bone Mineral Density Among Select Functional Foods and Bioactive Compounds
journal, April 2010


Dietary supplementation with dried plum prevents ovariectomy-induced bone loss while modulating the immune response in C57BL/6J mice
journal, January 2012


Dried plum prevents bone loss in a male osteoporosis model via IGF-I and the RANK pathway
journal, December 2006


Dried plum prevents bone loss in a male osteoporosis model via IGF-I and the RANK pathway
journal, December 2006


Effects of Dietary Supplements on the Space Radiation-Induced Reduction in Total Antioxidant Status in CBA Mice
journal, April 2006


Low-Dose, Ionizing Radiation and Age-Related Changes in Skeletal Microarchitecture
journal, January 2012


Bone mineral loss induced by anticancer treatment for gynecological malignancies in premenopausal women
journal, March 2013


Dietary supplementation with dried plum prevents ovariectomy-induced bone loss while modulating the immune response in C57BL/6J mice
journal, January 2012


Rabbiteye blueberry prevents osteoporosis in ovariectomized rats
journal, August 2014


The 21st-Century Landscape of Adult Fractures: Cohort Study of a Complete Adult Regional Population: ADULT FRACTURE EPIDEMIOLOGY WITH RECENT TIME TRENDS
journal, February 2015


Selective inhibition of TNFR1 reduces osteoclast numbers and is differentiated from anti-TNF in a LPS-driven model of inflammatory bone loss
journal, September 2015


A report from Fukushima: an assessment of bone health in an area affected by the Fukushima nuclear plant incident
journal, August 2013


Exposure to Ionizing Radiation and Development of Bone Sarcoma: New Insights Based on Atomic-Bomb Survivors of Hiroshima and Nagasaki
journal, January 2011


Dried Plum’s Unique Capacity to Reverse Bone Loss and Alter Bone Metabolism in Postmenopausal Osteoporosis Model
journal, March 2013


Risedronate prevents early radiation-induced osteoporosis in mice at multiple skeletal locations
journal, January 2010


Evidence for anti-inflammatory and antioxidative properties of dried plum polyphenols in macrophage RAW 264.7 cells
journal, January 2015


Anti-hyperglycemic effects of plum in a rat model of obesity and type 2 diabetes, Wistar fatty rat
journal, January 2005


Space Radiation: The Number One Risk to Astronaut Health beyond Low Earth Orbit
journal, September 2014


Dietary Dried Plum Increases Bone Mass in Adult and Aged Male Mice
journal, August 2010


Dried Plum Polyphenols Inhibit Osteoclastogenesis by Downregulating NFATc1 and Inflammatory Mediators
journal, May 2008


Predominant contribution of the dose received from constituent heavy-ions in the induction of gastrointestinal tumorigenesis after simulated space radiation exposure
journal, September 2022


Trabecular bone architecture in the pathogenesis and prevention of fracture
journal, January 1987


Short-Term Effects of Whole-Body Exposure to 56 Fe Ions in Combination with Musculoskeletal Disuse on Bone Cells
journal, April 2010


Early Increase in Osteoclast Number in Mice after Whole-Body Irradiation with 2 Gy X Rays
journal, September 2008


Dried plum polyphenols attenuate the detrimental effects of TNF-α on osteoblast function coincident with up-regulation of Runx2, Osterix and IGF-I
journal, January 2009


Space Radiation: The Number One Risk to Astronaut Health beyond Low Earth Orbit
journal, September 2014


Men and Women in Space: Bone Loss and Kidney Stone Risk After Long-Duration Spaceflight: BONE LOSS AND KIDNEY STONE RISK IN SPACEFLIGHT
journal, June 2014


Phytonutrients for bone health during ageing: Phytonutrients for bone health
journal, February 2013


Effect of proton irradiation followed by hindlimb unloading on bone in mature mice: A model of long-duration spaceflight
text, January 2012


Bone remodelling in inflammatory arthritis
journal, December 2012


Spaceflight-relevant types of ionizing radiation and cortical bone: Potential LET effect?
journal, December 2008


Dried Plums and Their Products: Composition and Health Effects–An Updated Review
journal, January 2013


Sclerostin inhibition: a novel therapeutic approach in the treatment of osteoporosis
journal, June 2015


Chemotherapy- and Irradiation-Induced Bone Loss in Adults with Solid Tumors
journal, February 2015


The 21st-Century Landscape of Adult Fractures: Cohort Study of a Complete Adult Regional Population: ADULT FRACTURE EPIDEMIOLOGY WITH RECENT TIME TRENDS
journal, February 2015


Dietary Dried Plum Increases Bone Mass in Adult and Aged Male Mice
journal, August 2010


Addition of Fructooligosaccharides and Dried Plum to Soy-Based Diets Reverses Bone Loss in the Ovariectomized Rat
journal, January 2011


Ionizing Radiation Stimulates Expression of Pro-Osteoclastogenic Genes in Marrow and Skeletal Tissue
journal, June 2015


Historical height loss, vertebral deformity, and health-related quality of life in Hiroshima cohort study
journal, June 2007


Risedronate prevents early radiation-induced osteoporosis in mice at multiple skeletal locations
journal, January 2010


Measurements of Energetic Particle Radiation in Transit to Mars on the Mars Science Laboratory
journal, May 2013


Effects of Dried Plum Supplementation on Bone Metabolism in Adult C57BL/6 Male Mice
journal, December 2013


Dried Fruits: Excellent in Vitro and in Vivo Antioxidants
journal, February 2005


Oxidative stress and gamma radiation-induced cancellous bone loss with musculoskeletal disuse
journal, January 2010


Phytonutrients for bone health during ageing: Phytonutrients for bone health
journal, February 2013


A report from Fukushima: an assessment of bone health in an area affected by the Fukushima nuclear plant incident
journal, August 2013


Spaceflight-relevant types of ionizing radiation and cortical bone: Potential LET effect?
journal, December 2008


Bisphosphonates in the treatment of patients with lung cancer and metastatic bone disease: a systematic review and meta-analysis
journal, September 2012


Bone remodelling in inflammatory arthritis
journal, December 2012


Bone mineral loss induced by anticancer treatment for gynecological malignancies in premenopausal women
journal, March 2013


Low-Dose, Ionizing Radiation and Age-Related Changes in Skeletal Microarchitecture
journal, January 2012


Dietary Antioxidants Protect Hematopoietic Cells and Improve Animal Survival after Total-Body Irradiation
journal, April 2008


Oxidative stress response and Nrf2 signaling in aging
journal, November 2015


Works referencing / citing this record:

Dried Plums, Prunes and Bone Health: A Comprehensive Review
journal, April 2017


Dried Plums, Prunes and Bone Health: A Comprehensive Review
journal, April 2017


A Moderate Daily Dose of Resveratrol Mitigates Muscle Deconditioning in a Martian Gravity Analog
journal, July 2019


Radiation-Induced Bone Toxicity
journal, October 2017


Establishing mechanisms affecting the individual response to ionizing radiation
journal, January 2020


Effects of Iron Overload and Oxidative Damage on the Musculoskeletal System in the Space Environment: Data from Spaceflights and Ground-Based Simulation Models
journal, September 2018


A Moderate Daily Dose of Resveratrol Mitigates Muscle Deconditioning in a Martian Gravity Analog
journal, July 2019


Effects of Iron Overload and Oxidative Damage on the Musculoskeletal System in the Space Environment: Data from Spaceflights and Ground-Based Simulation Models
journal, September 2018


Ionizing Radiation Exacerbates the Bone Loss Induced by Iron Overload in Mice
journal, November 2019


Therapeutic ionizing radiation induced bone loss: a review of in vivo and in vitro findings
journal, March 2018


Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight
journal, October 2017