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Title: Discovery of 1-(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a Pan-RAF Inhibitor with Minimal Paradoxical Activation and Activity against BRAF or RAS Mutant Tumor Cells

Authors:
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  1. Emerald
  2. (
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
INDUSTRY
OSTI Identifier:
1240168
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Medicinal Chemistry; Journal Volume: 58; Journal Issue: (10) ; 05, 2015
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Henry, James R., Kaufman, Michael D., Peng, Sheng-Bin, Ahn, Yu Mi, Caldwell, Timothy M., Vogeti, Lakshminarayana, Telikepalli, Hanumaiah, Lu, Wei-Ping, Hood, Molly M., Rutkoski, Thomas J., Smith, Bryan D., Vogeti, Subha, Miller, David, Wise, Scott C., Chun, Lawrence, Zhang, Xiaoyi, Zhang, Youyan, Kays, Lisa, Hipskind, Philip A., Wrobleski, Aaron D., Lobb, Karen L., Clay, Julia M., Cohen, Jeffrey D., Walgren, Jennie L., McCann, Denis, Patel, Phenil, Clawson, David K., Guo, Sherry, Manglicmot, Danalyn, Groshong, Chris, Logan, Cheyenne, Starling, James J., Flynn, Daniel L., Deciphera), and Lilly). Discovery of 1-(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a Pan-RAF Inhibitor with Minimal Paradoxical Activation and Activity against BRAF or RAS Mutant Tumor Cells. United States: N. p., 2016. Web. doi:10.1021/acs.jmedchem.5b00067.
Henry, James R., Kaufman, Michael D., Peng, Sheng-Bin, Ahn, Yu Mi, Caldwell, Timothy M., Vogeti, Lakshminarayana, Telikepalli, Hanumaiah, Lu, Wei-Ping, Hood, Molly M., Rutkoski, Thomas J., Smith, Bryan D., Vogeti, Subha, Miller, David, Wise, Scott C., Chun, Lawrence, Zhang, Xiaoyi, Zhang, Youyan, Kays, Lisa, Hipskind, Philip A., Wrobleski, Aaron D., Lobb, Karen L., Clay, Julia M., Cohen, Jeffrey D., Walgren, Jennie L., McCann, Denis, Patel, Phenil, Clawson, David K., Guo, Sherry, Manglicmot, Danalyn, Groshong, Chris, Logan, Cheyenne, Starling, James J., Flynn, Daniel L., Deciphera), & Lilly). Discovery of 1-(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a Pan-RAF Inhibitor with Minimal Paradoxical Activation and Activity against BRAF or RAS Mutant Tumor Cells. United States. doi:10.1021/acs.jmedchem.5b00067.
Henry, James R., Kaufman, Michael D., Peng, Sheng-Bin, Ahn, Yu Mi, Caldwell, Timothy M., Vogeti, Lakshminarayana, Telikepalli, Hanumaiah, Lu, Wei-Ping, Hood, Molly M., Rutkoski, Thomas J., Smith, Bryan D., Vogeti, Subha, Miller, David, Wise, Scott C., Chun, Lawrence, Zhang, Xiaoyi, Zhang, Youyan, Kays, Lisa, Hipskind, Philip A., Wrobleski, Aaron D., Lobb, Karen L., Clay, Julia M., Cohen, Jeffrey D., Walgren, Jennie L., McCann, Denis, Patel, Phenil, Clawson, David K., Guo, Sherry, Manglicmot, Danalyn, Groshong, Chris, Logan, Cheyenne, Starling, James J., Flynn, Daniel L., Deciphera), and Lilly). Thu . "Discovery of 1-(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a Pan-RAF Inhibitor with Minimal Paradoxical Activation and Activity against BRAF or RAS Mutant Tumor Cells". United States. doi:10.1021/acs.jmedchem.5b00067.
@article{osti_1240168,
title = {Discovery of 1-(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a Pan-RAF Inhibitor with Minimal Paradoxical Activation and Activity against BRAF or RAS Mutant Tumor Cells},
author = {Henry, James R. and Kaufman, Michael D. and Peng, Sheng-Bin and Ahn, Yu Mi and Caldwell, Timothy M. and Vogeti, Lakshminarayana and Telikepalli, Hanumaiah and Lu, Wei-Ping and Hood, Molly M. and Rutkoski, Thomas J. and Smith, Bryan D. and Vogeti, Subha and Miller, David and Wise, Scott C. and Chun, Lawrence and Zhang, Xiaoyi and Zhang, Youyan and Kays, Lisa and Hipskind, Philip A. and Wrobleski, Aaron D. and Lobb, Karen L. and Clay, Julia M. and Cohen, Jeffrey D. and Walgren, Jennie L. and McCann, Denis and Patel, Phenil and Clawson, David K. and Guo, Sherry and Manglicmot, Danalyn and Groshong, Chris and Logan, Cheyenne and Starling, James J. and Flynn, Daniel L. and Deciphera) and Lilly)},
abstractNote = {},
doi = {10.1021/acs.jmedchem.5b00067},
journal = {Journal of Medicinal Chemistry},
number = (10) ; 05, 2015,
volume = 58,
place = {United States},
year = {Thu Jul 07 00:00:00 EDT 2016},
month = {Thu Jul 07 00:00:00 EDT 2016}
}