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Title: Preparation of highly luminescent and color tunable carbon nanodots under visible light excitation for in vitro and in vivo bio-imaging

Journal Article · · Journal of Materials Research
DOI:https://doi.org/10.1557/jmr.2015.323· OSTI ID:1240098
 [1];  [2];  [2];  [3];  [3];  [2];  [4];  [5];  [2]
  1. Beijing Univ. of Technology, Beijing (China)
  2. Chinese Academy of Sciences, Jilin, (People's Republic of China)
  3. Chinese Academy of Sciences, Jilin (People's Republic of China)
  4. Beijing Univ. of Technology, Beijing (People's Republic of China); Chinese Academy of Sciences, Jilin, (People's Republic of China)
  5. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Univ. of New Mexico, Albuquerque, NM (United States)
+ Show Author Affiliations

Carbon nanodots (CDs) have generated enormous excitement because of their superiority in water solubility, chemical inertness, low toxicity, ease of functionalization and resistance to photobleaching. Here we report a facile thermal pyrolysis route to prepare CDs with high quantum yield (QY) using citric acid as the carbon source and ethylene diamine derivatives (EDAs) including triethylenetetramine (TETA), tetraethylenepentamine (TEPA) and polyene polyamine (PEPA) as the passivation agents. We find that the CDs prepared from EDAs, such as TETA, TEPA and PEPA, show relatively high photoluminescence (PL) QY (11.4, 10.6, and 9.8%, respectively) at 1ex of 465 nm. The cytotoxicity of the CDs has been investigated through in vitro and in vivo bio-imaging studies. The results indicate that these CDs possess low toxicity and good biocompatibility. As a result, the unique properties such as the high PL QY at large excitation wave length and the low toxicity of the resulting CDs make them promising fluorescent nanoprobes for applications in optical bio-imaging and biosensing.

Research Organization:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
Grant/Contract Number:
AC04-94AL85000
OSTI ID:
1240098
Report Number(s):
SAND2016-0800J; 618955
Journal Information:
Journal of Materials Research, Vol. 30, Issue 22; ISSN 0884-2914
Publisher:
Materials Research SocietyCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 16 works
Citation information provided by
Web of Science

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Cited By (3)

Graphene quantum dot-based theranostic agents for active targeting of breast cancer journal January 2017
Facile and scalable preparation of highly luminescent N,S co-doped graphene quantum dots and their application for parallel detection of multiple metal ions journal January 2017
Short-wave infrared emitted/excited fluorescence from carbon dots and preliminary applications in bioimaging journal January 2018

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