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Title: Engineering antigen-specific immunological tolerance.

Abstract

Unwanted immunity develops in response to many protein drugs, in autoimmunity, in allergy, and in transplantation. Approaches to induce immunological tolerance aim to either prevent these responses or reverse them after they have already taken place. We present here recent developments in approaches, based on engineered peptides, proteins and biomaterials, that harness mechanisms of peripheral tolerance both prophylactically and therapeutically to induce antigenspecific immunological tolerance. These mechanisms are based on responses of B and T lymphocytes to other cells in their immune environment that result in cellular deletion or ignorance to particular antigens, or in development of active immune regulatory responses. Several of these approaches are moving toward clinical development, and some are already in early stages of clinical testing.

Authors:
; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE Office of Science - Office of Basic Energy Sciences - Materials Sciences and Engineering Division
OSTI Identifier:
1238793
DOE Contract Number:  
AC02-06CH11357
Resource Type:
Journal Article
Journal Name:
Current Opinion in Immunology
Additional Journal Information:
Journal Volume: 35; Journal ID: ISSN 0952-7915
Country of Publication:
United States
Language:
English

Citation Formats

Kontos, Stephan, Grimm, Alizee J., and Hubbell, Jeffrey A. Engineering antigen-specific immunological tolerance.. United States: N. p., 2015. Web. doi:10.1016/j.coi.2015.05.005.
Kontos, Stephan, Grimm, Alizee J., & Hubbell, Jeffrey A. Engineering antigen-specific immunological tolerance.. United States. doi:10.1016/j.coi.2015.05.005.
Kontos, Stephan, Grimm, Alizee J., and Hubbell, Jeffrey A. Fri . "Engineering antigen-specific immunological tolerance.". United States. doi:10.1016/j.coi.2015.05.005.
@article{osti_1238793,
title = {Engineering antigen-specific immunological tolerance.},
author = {Kontos, Stephan and Grimm, Alizee J. and Hubbell, Jeffrey A.},
abstractNote = {Unwanted immunity develops in response to many protein drugs, in autoimmunity, in allergy, and in transplantation. Approaches to induce immunological tolerance aim to either prevent these responses or reverse them after they have already taken place. We present here recent developments in approaches, based on engineered peptides, proteins and biomaterials, that harness mechanisms of peripheral tolerance both prophylactically and therapeutically to induce antigenspecific immunological tolerance. These mechanisms are based on responses of B and T lymphocytes to other cells in their immune environment that result in cellular deletion or ignorance to particular antigens, or in development of active immune regulatory responses. Several of these approaches are moving toward clinical development, and some are already in early stages of clinical testing.},
doi = {10.1016/j.coi.2015.05.005},
journal = {Current Opinion in Immunology},
issn = {0952-7915},
number = ,
volume = 35,
place = {United States},
year = {2015},
month = {5}
}