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Title: Polymer scaffold degradation control via chemical control

Abstract

A variety of polymers and copolymers suitable for use as biologically compatible constructs and, as a non-limiting specific example, in the formation of degradable tissue scaffolds as well methods for synthesizing these polymers and copolymers are described. The polymers and copolymers have degradation rates that are substantially faster than those of previously described polymers suitable for the same uses. Copolymers having a synthesis route which enables one to fine tune the degradation rate by selecting the specific stoichiometry of the monomers in the resulting copolymer are also described. The disclosure also provides a novel synthesis route for maleoyl chloride which yields monomers suitable for use in the copolymer synthesis methods described herein.

Inventors:
; ;
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1234693
Patent Number(s):
9,228,042
Application Number:
14/147,983
Assignee:
STC.UNM (Albuquerque, NM) SNL-A
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Jan 06
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Hedberg-Dirk, Elizabeth L., Dirk, Shawn, and Cicotte, Kirsten. Polymer scaffold degradation control via chemical control. United States: N. p., 2016. Web.
Hedberg-Dirk, Elizabeth L., Dirk, Shawn, & Cicotte, Kirsten. Polymer scaffold degradation control via chemical control. United States.
Hedberg-Dirk, Elizabeth L., Dirk, Shawn, and Cicotte, Kirsten. Tue . "Polymer scaffold degradation control via chemical control". United States. doi:. https://www.osti.gov/servlets/purl/1234693.
@article{osti_1234693,
title = {Polymer scaffold degradation control via chemical control},
author = {Hedberg-Dirk, Elizabeth L. and Dirk, Shawn and Cicotte, Kirsten},
abstractNote = {A variety of polymers and copolymers suitable for use as biologically compatible constructs and, as a non-limiting specific example, in the formation of degradable tissue scaffolds as well methods for synthesizing these polymers and copolymers are described. The polymers and copolymers have degradation rates that are substantially faster than those of previously described polymers suitable for the same uses. Copolymers having a synthesis route which enables one to fine tune the degradation rate by selecting the specific stoichiometry of the monomers in the resulting copolymer are also described. The disclosure also provides a novel synthesis route for maleoyl chloride which yields monomers suitable for use in the copolymer synthesis methods described herein.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 05 00:00:00 EST 2016},
month = {Tue Jan 05 00:00:00 EST 2016}
}

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