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Title: Genomic Perspectives of Transcriptional Regulation in Forebrain Development

Abstract

The forebrain is the seat of higher-order brain functions, and many human neuropsychiatric disorders are due to genetic defects affecting forebrain development, making it imperative to understand the underlying genetic circuitry. We report that recent progress now makes it possible to begin fully elucidating the genomic regulatory mechanisms that control forebrain gene expression. Here, we discuss the current knowledge of how transcription factors drive gene expression programs through their interactions with cis-acting genomic elements, such as enhancers; how analyses of chromatin and DNA modifications provide insights into gene expression states; and how these approaches yield insights into the evolution of the human brain.

Authors:
 [1];  [2];  [3];  [2]
  1. Univ. of California, Davis, CA (United States)
  2. Univ. of California, San Francisco, CA (United States)
  3. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); DOE Joint Genome Inst., Walnut Creek, CA (United States); Univ. of California, Merced, CA (United States)
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1234146
Alternate Identifier(s):
OSTI ID: 1257835
Grant/Contract Number:
AC02-05CH11231; GM105202; R01NS062859A; R01HG003988; R01NS34661; R01MH081880; R37MH049428; T32 GMO7618
Resource Type:
Journal Article: Published Article
Journal Name:
Neuron
Additional Journal Information:
Journal Volume: 85; Journal Issue: 1; Journal ID: ISSN 0896-6273
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Nord, Alex S., Pattabiraman, Kartik, Visel, Axel, and Rubenstein, John L. R. Genomic Perspectives of Transcriptional Regulation in Forebrain Development. United States: N. p., 2015. Web. doi:10.1016/j.neuron.2014.11.011.
Nord, Alex S., Pattabiraman, Kartik, Visel, Axel, & Rubenstein, John L. R. Genomic Perspectives of Transcriptional Regulation in Forebrain Development. United States. doi:10.1016/j.neuron.2014.11.011.
Nord, Alex S., Pattabiraman, Kartik, Visel, Axel, and Rubenstein, John L. R. Wed . "Genomic Perspectives of Transcriptional Regulation in Forebrain Development". United States. doi:10.1016/j.neuron.2014.11.011.
@article{osti_1234146,
title = {Genomic Perspectives of Transcriptional Regulation in Forebrain Development},
author = {Nord, Alex S. and Pattabiraman, Kartik and Visel, Axel and Rubenstein, John L. R.},
abstractNote = {The forebrain is the seat of higher-order brain functions, and many human neuropsychiatric disorders are due to genetic defects affecting forebrain development, making it imperative to understand the underlying genetic circuitry. We report that recent progress now makes it possible to begin fully elucidating the genomic regulatory mechanisms that control forebrain gene expression. Here, we discuss the current knowledge of how transcription factors drive gene expression programs through their interactions with cis-acting genomic elements, such as enhancers; how analyses of chromatin and DNA modifications provide insights into gene expression states; and how these approaches yield insights into the evolution of the human brain.},
doi = {10.1016/j.neuron.2014.11.011},
journal = {Neuron},
number = 1,
volume = 85,
place = {United States},
year = {Wed Jan 07 00:00:00 EST 2015},
month = {Wed Jan 07 00:00:00 EST 2015}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record at 10.1016/j.neuron.2014.11.011

Citation Metrics:
Cited by: 33 works
Citation information provided by
Web of Science

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