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Title: Bacterial microcompartments and the modular construction of microbial metabolism

Publication Date:
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
Grant/Contract Number:
AC02 05CH11231
Resource Type:
Journal Article: Publisher's Accepted Manuscript
Journal Name:
Trends in Microbiology
Additional Journal Information:
Journal Volume: 23; Journal Issue: 1; Related Information: CHORUS Timestamp: 2017-05-29 09:19:22; Journal ID: ISSN 0966-842X
Country of Publication:
Country unknown/Code not available

Citation Formats

Kerfeld, Cheryl A., and Erbilgin, Onur. Bacterial microcompartments and the modular construction of microbial metabolism. Country unknown/Code not available: N. p., 2015. Web. doi:10.1016/j.tim.2014.10.003.
Kerfeld, Cheryl A., & Erbilgin, Onur. Bacterial microcompartments and the modular construction of microbial metabolism. Country unknown/Code not available. doi:10.1016/j.tim.2014.10.003.
Kerfeld, Cheryl A., and Erbilgin, Onur. 2015. "Bacterial microcompartments and the modular construction of microbial metabolism". Country unknown/Code not available. doi:10.1016/j.tim.2014.10.003.
title = {Bacterial microcompartments and the modular construction of microbial metabolism},
author = {Kerfeld, Cheryl A. and Erbilgin, Onur},
abstractNote = {},
doi = {10.1016/j.tim.2014.10.003},
journal = {Trends in Microbiology},
number = 1,
volume = 23,
place = {Country unknown/Code not available},
year = 2015,
month = 1

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record at 10.1016/j.tim.2014.10.003

Citation Metrics:
Cited by: 44works
Citation information provided by
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  • - Carboxysomes are part of the carbon concentrating mechanism in cyanobacteria and chemoautotrophs. - Carboxysomes are a subclass of bacterial microcompartments (BMCs); BMCs can encapsulate a range of metabolic processes. - Like some viral particles, the carboxysome can be modeled as an icosahedron-in its case, having 4,000-5,000 hexameric shell subunits and 12 surface pentamers to generate curvature. - The threefold axis of symmetry of the CsoS1D protein in carboxysomes forms a pore that can open and close, allowing for selective diffusion. - Genetic modules encoding BMC shell proteins and the enzymes that they encapsulate are horizontally transferable, suggesting they enablemore » bacteria to adapt to diverse environments.« less
  • Bacterialmicrocompartments (BMCs) are organelles composed entirely of protein. They promote specific metabolic processes by encapsulatingand colocalizing enzymes with their substrates and cofactors, by protecting vulnerable enzymes in a defined microenvironment, and bysequestering toxic or volatile intermediates. Prototypes of the BMCsare the carboxysomes of autotrophic bacteria. However, structures of similarpolyhedral shape are being discovered in an ever-increasing number of heterotrophic bacteria, where they participate in the utilization ofspecialty carbon and energy sources.Comparative genomics reveals that the potential for this type of compartmentalization is widespread acrossbacterial phyla and suggests that genetic modules encoding BMCs are frequently laterally transferred among bacteria. The diversemore » functionsof these BMCs suggest that they contribute to metabolic innovation in bacteria in a broad range of environments.« less
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  • Secondary metabolites produced by microbes have diverse biological functions, which makes them a great potential source of biotechnologically relevant compounds with antimicrobial, anti-cancer and other activities. The proteins needed to synthesize these natural products are often encoded by clusters of co-located genes called biosynthetic gene clusters (BCs). In order to advance the exploration of microbial secondary metabolism, we developed the largest publically available database of experimentally verified and predicted BCs, the Integrated Microbial Genomes Atlas of Biosynthetic gene Clusters (IMG-ABC) ( Here, we describe an update of IMG-ABC, which includes ClusterScout, a tool for targeted identification of custom biosynthetic genemore » clusters across 40 000 isolate microbial genomes, and a new search capability to query more than 700 000 BCs from isolate genomes for clusters with similar Pfam composition. Additional features enable fast exploration and analysis of BCs through two new interactive visualization features, a BC function heatmap and a BC similarity network graph. These new tools and features add to the value of IMG-ABC's vast body of BC data, facilitating their in-depth analysis and accelerating secondary metabolite discovery.« less