Magnetic relaxometry as applied to sensitive cancer detection and localization
Abstract
Abstract Here we describe superparamagnetic relaxometry (SPMR), a technology that utilizes highly sensitive magnetic sensors and superparamagnetic nanoparticles for cancer detection. Using SPMR, we sensitively and specifically detect nanoparticles conjugated to biomarkers for various types of cancer. SPMR offers high contrast In SPMR measurements, a brief magnetizing pulse is used to align superparamagnetic nanoparticles of a discrete size. Following the pulse, an array of superconducting quantum interference detectors (SQUID) sensors detect the decaying magnetization field. NP size is chosen so that, when bound, the induced field decays in seconds. They are functionalized with specific biomarkers and incubated with cancer cells As a result, superparamagnetic NPs developed here have small size dispersion. Cell incubation studies measure specificity for different cell lines and antibodies with very high contrast.
- Authors:
-
- Senior Scientific LLC, Albuquerque, NM (United States)
- Univ. of New Mexico School of Medicine, Albuquerque, NM (United States)
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); AC52-06NA25396
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA)
- OSTI Identifier:
- 1227725
- Alternate Identifier(s):
- OSTI ID: 1237695; OSTI ID: 1248338
- Report Number(s):
- LA-UR-15-21938; SAND-2015-6922J
Journal ID: ISSN 0013-5585
- Grant/Contract Number:
- AC52-06NA25396; AC04-94AL85000; SC0008810
- Resource Type:
- Journal Article: Accepted Manuscript
- Journal Name:
- Biomedizinische Technik
- Additional Journal Information:
- Journal Volume: 60; Journal Issue: 5; Journal ID: ISSN 0013-5585
- Publisher:
- De Gruyter
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; SQUID; magnetic relaxometry; nanoparticles; cancer; 77 NANOSCIENCE AND NANOTECHNOLOGY; magnetic; relaxometry
Citation Formats
De Haro, Leyma P., Karaulanov, Todor, Vreeland, Erika C., Anderson, Bill, Hathaway, Helen J., Huber, Dale L., Matlashov, Andrei N., Nettles, Christopher P., Price, Andrew D., Monson, Todd C., and Flynn, Edward R. Magnetic relaxometry as applied to sensitive cancer detection and localization. United States: N. p., 2015.
Web. doi:10.1515/bmt-2015-0053.
De Haro, Leyma P., Karaulanov, Todor, Vreeland, Erika C., Anderson, Bill, Hathaway, Helen J., Huber, Dale L., Matlashov, Andrei N., Nettles, Christopher P., Price, Andrew D., Monson, Todd C., & Flynn, Edward R. Magnetic relaxometry as applied to sensitive cancer detection and localization. United States. https://doi.org/10.1515/bmt-2015-0053
De Haro, Leyma P., Karaulanov, Todor, Vreeland, Erika C., Anderson, Bill, Hathaway, Helen J., Huber, Dale L., Matlashov, Andrei N., Nettles, Christopher P., Price, Andrew D., Monson, Todd C., and Flynn, Edward R. 2015.
"Magnetic relaxometry as applied to sensitive cancer detection and localization". United States. https://doi.org/10.1515/bmt-2015-0053. https://www.osti.gov/servlets/purl/1227725.
@article{osti_1227725,
title = {Magnetic relaxometry as applied to sensitive cancer detection and localization},
author = {De Haro, Leyma P. and Karaulanov, Todor and Vreeland, Erika C. and Anderson, Bill and Hathaway, Helen J. and Huber, Dale L. and Matlashov, Andrei N. and Nettles, Christopher P. and Price, Andrew D. and Monson, Todd C. and Flynn, Edward R.},
abstractNote = {Abstract Here we describe superparamagnetic relaxometry (SPMR), a technology that utilizes highly sensitive magnetic sensors and superparamagnetic nanoparticles for cancer detection. Using SPMR, we sensitively and specifically detect nanoparticles conjugated to biomarkers for various types of cancer. SPMR offers high contrast In SPMR measurements, a brief magnetizing pulse is used to align superparamagnetic nanoparticles of a discrete size. Following the pulse, an array of superconducting quantum interference detectors (SQUID) sensors detect the decaying magnetization field. NP size is chosen so that, when bound, the induced field decays in seconds. They are functionalized with specific biomarkers and incubated with cancer cells As a result, superparamagnetic NPs developed here have small size dispersion. Cell incubation studies measure specificity for different cell lines and antibodies with very high contrast.},
doi = {10.1515/bmt-2015-0053},
url = {https://www.osti.gov/biblio/1227725},
journal = {Biomedizinische Technik},
issn = {0013-5585},
number = 5,
volume = 60,
place = {United States},
year = {Tue Jun 02 00:00:00 EDT 2015},
month = {Tue Jun 02 00:00:00 EDT 2015}
}
Web of Science
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- Superconductor Science and Technology, Vol. 30, Issue 5
Spin waves across three-dimensional, close-packed nanoparticles
journal, December 2018
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