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Title: Magnetic relaxometry as applied to sensitive cancer detection and localization

Abstract

Abstract Here we describe superparamagnetic relaxometry (SPMR), a technology that utilizes highly sensitive magnetic sensors and superparamagnetic nanoparticles for cancer detection. Using SPMR, we sensitively and specifically detect nanoparticles conjugated to biomarkers for various types of cancer. SPMR offers high contrast In SPMR measurements, a brief magnetizing pulse is used to align superparamagnetic nanoparticles of a discrete size. Following the pulse, an array of superconducting quantum interference detectors (SQUID) sensors detect the decaying magnetization field. NP size is chosen so that, when bound, the induced field decays in seconds. They are functionalized with specific biomarkers and incubated with cancer cells As a result, superparamagnetic NPs developed here have small size dispersion. Cell incubation studies measure specificity for different cell lines and antibodies with very high contrast.

Authors:
 [1];  [1];  [1];  [1];  [2];  [3];  [4];  [1];  [1];  [3];  [1]
  1. Senior Scientific LLC, Albuquerque, NM (United States)
  2. Univ. of New Mexico School of Medicine, Albuquerque, NM (United States)
  3. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
  4. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); AC52-06NA25396
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1227725
Alternate Identifier(s):
OSTI ID: 1237695; OSTI ID: 1248338
Report Number(s):
LA-UR-15-21938; SAND-2015-6922J
Journal ID: ISSN 0013-5585
Grant/Contract Number:  
AC52-06NA25396; AC04-94AL85000; SC0008810
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Biomedizinische Technik
Additional Journal Information:
Journal Volume: 60; Journal Issue: 5; Journal ID: ISSN 0013-5585
Publisher:
De Gruyter
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; SQUID; magnetic relaxometry; nanoparticles; cancer; 77 NANOSCIENCE AND NANOTECHNOLOGY; magnetic; relaxometry

Citation Formats

De Haro, Leyma P., Karaulanov, Todor, Vreeland, Erika C., Anderson, Bill, Hathaway, Helen J., Huber, Dale L., Matlashov, Andrei N., Nettles, Christopher P., Price, Andrew D., Monson, Todd C., and Flynn, Edward R. Magnetic relaxometry as applied to sensitive cancer detection and localization. United States: N. p., 2015. Web. doi:10.1515/bmt-2015-0053.
De Haro, Leyma P., Karaulanov, Todor, Vreeland, Erika C., Anderson, Bill, Hathaway, Helen J., Huber, Dale L., Matlashov, Andrei N., Nettles, Christopher P., Price, Andrew D., Monson, Todd C., & Flynn, Edward R. Magnetic relaxometry as applied to sensitive cancer detection and localization. United States. https://doi.org/10.1515/bmt-2015-0053
De Haro, Leyma P., Karaulanov, Todor, Vreeland, Erika C., Anderson, Bill, Hathaway, Helen J., Huber, Dale L., Matlashov, Andrei N., Nettles, Christopher P., Price, Andrew D., Monson, Todd C., and Flynn, Edward R. 2015. "Magnetic relaxometry as applied to sensitive cancer detection and localization". United States. https://doi.org/10.1515/bmt-2015-0053. https://www.osti.gov/servlets/purl/1227725.
@article{osti_1227725,
title = {Magnetic relaxometry as applied to sensitive cancer detection and localization},
author = {De Haro, Leyma P. and Karaulanov, Todor and Vreeland, Erika C. and Anderson, Bill and Hathaway, Helen J. and Huber, Dale L. and Matlashov, Andrei N. and Nettles, Christopher P. and Price, Andrew D. and Monson, Todd C. and Flynn, Edward R.},
abstractNote = {Abstract Here we describe superparamagnetic relaxometry (SPMR), a technology that utilizes highly sensitive magnetic sensors and superparamagnetic nanoparticles for cancer detection. Using SPMR, we sensitively and specifically detect nanoparticles conjugated to biomarkers for various types of cancer. SPMR offers high contrast In SPMR measurements, a brief magnetizing pulse is used to align superparamagnetic nanoparticles of a discrete size. Following the pulse, an array of superconducting quantum interference detectors (SQUID) sensors detect the decaying magnetization field. NP size is chosen so that, when bound, the induced field decays in seconds. They are functionalized with specific biomarkers and incubated with cancer cells As a result, superparamagnetic NPs developed here have small size dispersion. Cell incubation studies measure specificity for different cell lines and antibodies with very high contrast.},
doi = {10.1515/bmt-2015-0053},
url = {https://www.osti.gov/biblio/1227725}, journal = {Biomedizinische Technik},
issn = {0013-5585},
number = 5,
volume = 60,
place = {United States},
year = {Tue Jun 02 00:00:00 EDT 2015},
month = {Tue Jun 02 00:00:00 EDT 2015}
}

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Cited by: 26 works
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Works referenced in this record:

Characterization of single-core magnetite nanoparticles for magnetic imaging by SQUID relaxometry
journal, September 2010


A biomagnetic system for in vivo cancer imaging
journal, March 2005


Some theoretical aspects of rock-magnetism
journal, April 1955


Detection of breast cancer cells using targeted magnetic nanoparticles and ultra-sensitive magnetic field sensors
journal, October 2011


Works referencing / citing this record:

Temperature trends and correlation between SQUID superparamagnetic relaxometry and dc-magnetization on model iron-oxide nanoparticles
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Biosensing utilizing magnetic markers and superconducting quantum interference devices
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Spin waves across three-dimensional, close-packed nanoparticles
journal, December 2018