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Title: Development of the preterm infant gut microbiome: A research priority

Abstract

The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiome due to multiple factors, including physiological immaturity and prenatal/postnatal influences that disrupt the development of a normal gut flora. However, little is known about the developmental succession of the microbiota in preterm infants as they grow and mature. This review provides a synthesis of our understanding of the normal development of the infant gut microbiome and contrasts this with dysbiotic development in the VLBW infant. The role of human milk in normal gut microbial development is emphasized, along with the role of the gut microbiome in immune development and gastroenteric health. Current research provides evidence that the gut microbiome interacts extensively with many physiological systems and metabolic processes in the developing infant. However, to the best of our knowledge, there are currently no studies prospectively mapping the gut microbiome of VLBW infants through early childhood. This knowledge gap must be filled to inform a healthcare system that can provide for the growth, health, and development of VLBW infants. In conclusion, the study speculates about how the VLBW infants’ gut microbiome might function through host-microbe interactions to contribute to the sequelae of pretermmore » birth, including its influence on growth, development, and general health of the infant host.« less

Authors:
 [1];  [1];  [2];  [1];  [1];  [3]
  1. Univ. of South Florida, Tampa, FL (United States)
  2. Morsani College of Medicine, St. Petersburg, FL (United States)
  3. Argonne National Lab. (ANL), Argonne, IL (United States); Univ. of Chicago, IL (United States); Zhejiang Univ., Hangzhou (China)
Publication Date:
Research Org.:
Argonne National Laboratory (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1225363
Grant/Contract Number:  
AC02-06CH11357
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Microbiome
Additional Journal Information:
Journal Volume: 2; Journal Issue: 1; Journal ID: ISSN 2049-2618
Publisher:
BioMed Central
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; preterm infants; VLBW; gut microbiota; health

Citation Formats

Groer, Maureen W., Luciano, Angel A., Dishaw, Larry J., Ashmeade, Terri L., Miller, Elizabeth, and Gilbert, Jack A. Development of the preterm infant gut microbiome: A research priority. United States: N. p., 2014. Web. doi:10.1186/2049-2618-2-38.
Groer, Maureen W., Luciano, Angel A., Dishaw, Larry J., Ashmeade, Terri L., Miller, Elizabeth, & Gilbert, Jack A. Development of the preterm infant gut microbiome: A research priority. United States. https://doi.org/10.1186/2049-2618-2-38
Groer, Maureen W., Luciano, Angel A., Dishaw, Larry J., Ashmeade, Terri L., Miller, Elizabeth, and Gilbert, Jack A. 2014. "Development of the preterm infant gut microbiome: A research priority". United States. https://doi.org/10.1186/2049-2618-2-38. https://www.osti.gov/servlets/purl/1225363.
@article{osti_1225363,
title = {Development of the preterm infant gut microbiome: A research priority},
author = {Groer, Maureen W. and Luciano, Angel A. and Dishaw, Larry J. and Ashmeade, Terri L. and Miller, Elizabeth and Gilbert, Jack A.},
abstractNote = {The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiome due to multiple factors, including physiological immaturity and prenatal/postnatal influences that disrupt the development of a normal gut flora. However, little is known about the developmental succession of the microbiota in preterm infants as they grow and mature. This review provides a synthesis of our understanding of the normal development of the infant gut microbiome and contrasts this with dysbiotic development in the VLBW infant. The role of human milk in normal gut microbial development is emphasized, along with the role of the gut microbiome in immune development and gastroenteric health. Current research provides evidence that the gut microbiome interacts extensively with many physiological systems and metabolic processes in the developing infant. However, to the best of our knowledge, there are currently no studies prospectively mapping the gut microbiome of VLBW infants through early childhood. This knowledge gap must be filled to inform a healthcare system that can provide for the growth, health, and development of VLBW infants. In conclusion, the study speculates about how the VLBW infants’ gut microbiome might function through host-microbe interactions to contribute to the sequelae of preterm birth, including its influence on growth, development, and general health of the infant host.},
doi = {10.1186/2049-2618-2-38},
url = {https://www.osti.gov/biblio/1225363}, journal = {Microbiome},
issn = {2049-2618},
number = 1,
volume = 2,
place = {United States},
year = {Mon Oct 13 00:00:00 EDT 2014},
month = {Mon Oct 13 00:00:00 EDT 2014}
}

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Cited by: 162 works
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Developmental origins of obesity: Early feeding environments, infant growth, and the intestinal microbiome
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Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis
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Microbiota profile in feces of breast- and formula-fed newborns by using fluorescence in situ hybridization (FISH)
journal, December 2011


Toward Effective Probiotics for Autism and Other Neurodevelopmental Disorders
journal, December 2013


Immune-directed support of rich microbial communities in the gut has ancient roots
journal, November 2014


Human milk is a source of lactic acid bacteria for the infant gut
journal, December 2003


Dynamics and Clinical Evolution of Bacterial Gut Microflora in Extremely Premature Patients
journal, March 2011


Preterm Infant Linear Growth and Adiposity Gain: Trade-Offs for Later Weight Status and Intelligence Quotient
journal, December 2013


Inflammatory signaling in NEC: Role of NF-κB, cytokines and other inflammatory mediators
journal, February 2014


Commensal and probiotic bacteria may prevent NEC by maturing intestinal host defenses
journal, February 2014


Human gut microbiome viewed across age and geography
journal, May 2012


The human microbiome: at the interface of health and disease
journal, March 2012


The human gut microbiota: a dynamic interplay with the host from birth to senescence settled during childhood
journal, April 2014


Role of the Microbiome in Energy Regulation and Metabolism
journal, May 2014


Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch
journal, May 2013


Trajectories of Growth among Children Who Have Coronary Events as Adults
journal, October 2005


Is delivery by cesarean section a risk factor for food allergy?
journal, August 2003


Additional maternal and nonmaternal factors contribute to microbiota shaping in newborns
journal, September 2010


Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression
journal, February 2014


Patterned progression of bacterial populations in the premature infant gut
journal, August 2014


Influences of microbiota on intestinal immune system development
journal, May 1999


Antibiotic Exposure by 6 Months and Asthma and Allergy at 6 Years: Findings in a Cohort of 1,401 US Children
journal, December 2010


Sepsis From the Gut: The Enteric Habitat of Bacteria That Cause Late-Onset Neonatal Bloodstream Infections
journal, March 2014


The role of microbes and autoimmunity in the pathogenesis of neuropsychiatric illness
journal, January 2013


Prebiotic Oligosaccharides in Premature Infants
journal, January 2014


The neonatal bowel microbiome in health and infection
journal, January 2014


Neonatal cerebral morphometry and later risk of persistent inattention/hyperactivity in children born very preterm
journal, January 2014


Interactions Between the Microbiota and the Immune System
journal, June 2012


The individual-specific and diverse nature of the preterm infant microbiota
journal, January 2013


Antibiotic use and inflammatory bowel diseases in childhood
journal, October 2010


More than just a gut instinct–the potential interplay between a baby's nutrition, its gut microbiome, and the epigenome
journal, June 2013


Differences in gut microbiota composition between obese and lean children: a cross-sectional study
journal, January 2013


Microbes in the neonatal intensive care unit resemble those found in the gut of premature infants
journal, January 2014


The Role of Microbes in Developmental Immunologic Programming
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Development of the Human Infant Intestinal Microbiota
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Pediatric Fecal Microbiota Harbor Diverse and Novel Antibiotic Resistance Genes
journal, November 2013


Meconium Microbiome Analysis Identifies Bacteria Correlated with Premature Birth
journal, March 2014


Prenatal or Early-Life Exposure to Antibiotics and Risk of Childhood Asthma: A Systematic Review
journal, May 2011


Effect of Breast and Formula Feeding on Gut Microbiota Shaping in Newborns
journal, January 2012


Multi-Faceted Functions of Secretory IgA at Mucosal Surfaces
journal, January 2013


Effect of mother’s weight on infant’s microbiota acquisition, composition, and activity during early infancy: a prospective follow-up study initiated in early pregnancy
journal, September 2010


Health, Nutrition, and Cost Outcomes of Human Milk Feedings for Very Low Birthweight Infants
journal, November 2013


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Preterm infants with necrotising enterocolitis demonstrate an unbalanced gut microbiota
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Rate of establishing the gut microbiota in infancy has consequences for future health
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Impact of nutrition and rotavirus infection on the infant gut microbiota in a humanized pig model
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Effects of early life NICU stress on the developing gut microbiome
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Impact of prematurity and nutrition on the developing gut microbiome and preterm infant growth
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Dichotomous development of the gut microbiome in preterm infants
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Disruptions of the intestinal microbiome in necrotizing enterocolitis, short bowel syndrome, and Hirschsprung’s associated enterocolitis
journal, October 2015


Gut Microbiota: A Potential Regulator of Neurodevelopment
journal, February 2017


The Human Neonatal Gut Microbiome: A Brief Review
journal, March 2015


Effects of Probiotic Supplementation on the Gut Microbiota and Antibiotic Resistome Development in Preterm Infants
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Development and Function of the Intestinal Microbiome and Potential Implications for Pig Production
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What Pediatricians Should Know Before Studying Gut Microbiota
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Factors Affecting Gastrointestinal Microbiome Development in Neonates
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Exploring the Science behind Bifidobacterium breve M-16V in Infant Health
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The Evolving Microbiome from Pregnancy to Early Infancy: A Comprehensive Review
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