Over-expression of NADH-dependent oxidoreductase (fucO) for increasing furfural or 5-hydroxymethylfurfural tolerance
Patent
·
OSTI ID:1223111
The subject invention pertains to the discovery that the NADH-dependent propanediol oxidoreductase (FucO) can reduce furfural. This allows for a new approach to improve furfural tolerance in bacterial and/or yeast cells used to produce desired products. Thus, novel biocatalysts (bacterial, fungal or yeast cells) exhibiting increased tolerance to furfural and 5-hydroxymethylfurfural (5-HMF) are provided as are methods of making and using such biocatalysts for the production of a desired product.
- Research Organization:
- Univ. of Florida, Gainesville, FL (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG36-08GO88142
- Assignee:
- University of Florida Research Foundation, Inc. (Gainesville, FL)
- Patent Number(s):
- 9,157,102
- Application Number:
- 14/008,015
- OSTI ID:
- 1223111
- Resource Relation:
- Patent File Date: 2012 Mar 29
- Country of Publication:
- United States
- Language:
- English
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