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Title: Device for high spatial resolution chemical analysis of a sample and method of high spatial resolution chemical analysis

Abstract

A system and method for analyzing a chemical composition of a specimen are described. The system can include at least one pin; a sampling device configured to contact a liquid with a specimen on the at least one pin to form a testing solution; and a stepper mechanism configured to move the at least one pin and the sampling device relative to one another. The system can also include an analytical instrument for determining a chemical composition of the specimen from the testing solution. In particular, the systems and methods described herein enable chemical analysis of specimens, such as tissue, to be evaluated in a manner that the spatial-resolution is limited by the size of the pins used to obtain tissue samples, not the size of the sampling device used to solubilize the samples coupled to the pins.

Inventors:
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1222620
Patent Number(s):
9,153,425
Application Number:
12/873,412
Assignee:
UT-Battelle, LLC (Oak Ridge, TN) ORNL
DOE Contract Number:
AC05-00OR22725
Resource Type:
Patent
Resource Relation:
Patent File Date: 2010 Sep 01
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Van Berkel, Gary J. Device for high spatial resolution chemical analysis of a sample and method of high spatial resolution chemical analysis. United States: N. p., 2015. Web.
Van Berkel, Gary J. Device for high spatial resolution chemical analysis of a sample and method of high spatial resolution chemical analysis. United States.
Van Berkel, Gary J. Tue . "Device for high spatial resolution chemical analysis of a sample and method of high spatial resolution chemical analysis". United States. doi:. https://www.osti.gov/servlets/purl/1222620.
@article{osti_1222620,
title = {Device for high spatial resolution chemical analysis of a sample and method of high spatial resolution chemical analysis},
author = {Van Berkel, Gary J.},
abstractNote = {A system and method for analyzing a chemical composition of a specimen are described. The system can include at least one pin; a sampling device configured to contact a liquid with a specimen on the at least one pin to form a testing solution; and a stepper mechanism configured to move the at least one pin and the sampling device relative to one another. The system can also include an analytical instrument for determining a chemical composition of the specimen from the testing solution. In particular, the systems and methods described herein enable chemical analysis of specimens, such as tissue, to be evaluated in a manner that the spatial-resolution is limited by the size of the pins used to obtain tissue samples, not the size of the sampling device used to solubilize the samples coupled to the pins.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 06 00:00:00 EDT 2015},
month = {Tue Oct 06 00:00:00 EDT 2015}
}

Patent:

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