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Title: Multifunctional cellulase and hemicellulase

Abstract

A multifunctional polypeptide capable of hydrolyzing cellulosic materials, xylan, and mannan is disclosed. The polypeptide includes the catalytic core (cc) of Clostridium thermocellum Cthe_0797 (CelE), the cellulose-specific carbohydrate-binding module CBM3 of the cellulosome anchoring protein cohesion region (CipA) of Clostridium thermocellum (CBM3a), and a linker region interposed between the catalytic core and the cellulose-specific carbohydrate binding module. Methods of using the multifunctional polypeptide are also disclosed.

Inventors:
; ;
Publication Date:
Research Org.:
Wisconsin Alumni Research Foundation, Madison, WI (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1221980
Patent Number(s):
9,145,551
Application Number:
14/030,290
Assignee:
Wisconsin Alumni Research Foundation (Madison, WI) CHO
DOE Contract Number:  
FC02-07ER64494
Resource Type:
Patent
Resource Relation:
Patent File Date: 2013 Sep 18
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Fox, Brian G., Takasuka, Taichi, and Bianchetti, Christopher M.. Multifunctional cellulase and hemicellulase. United States: N. p., 2015. Web.
Fox, Brian G., Takasuka, Taichi, & Bianchetti, Christopher M.. Multifunctional cellulase and hemicellulase. United States.
Fox, Brian G., Takasuka, Taichi, and Bianchetti, Christopher M.. Tue . "Multifunctional cellulase and hemicellulase". United States. doi:. https://www.osti.gov/servlets/purl/1221980.
@article{osti_1221980,
title = {Multifunctional cellulase and hemicellulase},
author = {Fox, Brian G. and Takasuka, Taichi and Bianchetti, Christopher M.},
abstractNote = {A multifunctional polypeptide capable of hydrolyzing cellulosic materials, xylan, and mannan is disclosed. The polypeptide includes the catalytic core (cc) of Clostridium thermocellum Cthe_0797 (CelE), the cellulose-specific carbohydrate-binding module CBM3 of the cellulosome anchoring protein cohesion region (CipA) of Clostridium thermocellum (CBM3a), and a linker region interposed between the catalytic core and the cellulose-specific carbohydrate binding module. Methods of using the multifunctional polypeptide are also disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 29 00:00:00 EDT 2015},
month = {Tue Sep 29 00:00:00 EDT 2015}
}

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Works referenced in this record:

Multiple display of catalytic modules on a protein scaffold: Nano-fabrication of enzyme particles
journal, September 2007


A combined approach to improving large-scale production of tobacco etch virus protease
journal, September 2007

  • Blommel, Paul G.; Fox, Brian G.
  • Protein Expression and Purification, Vol. 55, Issue 1, p. 53-68
  • DOI: 10.1016/j.pep.2007.04.013