skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Comparative Efficacy of 177Lu and 90Y for Anti-CD20 Pretargeted Radioimmunotherapy in Murine Lymphoma Xenograft Models

Abstract

Pretargeted radioimmunotherapy (PRIT) is a multi-step method of selectively delivering high doses of radiotherapy to tumor cells while minimizing exposure to surrounding tissues. Yttrium-90 (90Y) and lutetium-177 (177Lu) are two of the most promising beta-particle emitting radionuclides used for radioimmunotherapy, which despite having similar chemistries differ distinctly in terms of radiophysical features. These differences may have important consequences for the absorbed dose to tumors and normal organs. Whereas 90Y has been successfully applied in a number of preclinical and clinical radioimmunotherapy settings, there have been few published pretargeting studies with 177Lu. We therefore compared the therapeutic potential of targeting either 90Y or 177Lu to human B-cell lymphoma xenografts in mice.

Authors:
; ; ; ; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1221461
Report Number(s):
PNNL-SA-111489
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Resource Relation:
Journal Name: PLoS One, 10(3):Article No. e0120561
Country of Publication:
United States
Language:
English

Citation Formats

Frost, Sophia, Frayo, Shani, Miller, Brian W., Orozco, Johnnie J., Booth, Garrett C., Hylarides, Mark, Lin, Yukang, Green, Damian J., Gopal, Ajay K., Pagel, John M., Back, Tom, Fisher, Darrell R., and Press, Oliver W. Comparative Efficacy of 177Lu and 90Y for Anti-CD20 Pretargeted Radioimmunotherapy in Murine Lymphoma Xenograft Models. United States: N. p., 2015. Web. doi:10.1371/journal.pone.0120561.
Frost, Sophia, Frayo, Shani, Miller, Brian W., Orozco, Johnnie J., Booth, Garrett C., Hylarides, Mark, Lin, Yukang, Green, Damian J., Gopal, Ajay K., Pagel, John M., Back, Tom, Fisher, Darrell R., & Press, Oliver W. Comparative Efficacy of 177Lu and 90Y for Anti-CD20 Pretargeted Radioimmunotherapy in Murine Lymphoma Xenograft Models. United States. doi:10.1371/journal.pone.0120561.
Frost, Sophia, Frayo, Shani, Miller, Brian W., Orozco, Johnnie J., Booth, Garrett C., Hylarides, Mark, Lin, Yukang, Green, Damian J., Gopal, Ajay K., Pagel, John M., Back, Tom, Fisher, Darrell R., and Press, Oliver W. Sun . "Comparative Efficacy of 177Lu and 90Y for Anti-CD20 Pretargeted Radioimmunotherapy in Murine Lymphoma Xenograft Models". United States. doi:10.1371/journal.pone.0120561.
@article{osti_1221461,
title = {Comparative Efficacy of 177Lu and 90Y for Anti-CD20 Pretargeted Radioimmunotherapy in Murine Lymphoma Xenograft Models},
author = {Frost, Sophia and Frayo, Shani and Miller, Brian W. and Orozco, Johnnie J. and Booth, Garrett C. and Hylarides, Mark and Lin, Yukang and Green, Damian J. and Gopal, Ajay K. and Pagel, John M. and Back, Tom and Fisher, Darrell R. and Press, Oliver W.},
abstractNote = {Pretargeted radioimmunotherapy (PRIT) is a multi-step method of selectively delivering high doses of radiotherapy to tumor cells while minimizing exposure to surrounding tissues. Yttrium-90 (90Y) and lutetium-177 (177Lu) are two of the most promising beta-particle emitting radionuclides used for radioimmunotherapy, which despite having similar chemistries differ distinctly in terms of radiophysical features. These differences may have important consequences for the absorbed dose to tumors and normal organs. Whereas 90Y has been successfully applied in a number of preclinical and clinical radioimmunotherapy settings, there have been few published pretargeting studies with 177Lu. We therefore compared the therapeutic potential of targeting either 90Y or 177Lu to human B-cell lymphoma xenografts in mice.},
doi = {10.1371/journal.pone.0120561},
journal = {PLoS One, 10(3):Article No. e0120561},
number = ,
volume = ,
place = {United States},
year = {Sun Mar 01 00:00:00 EST 2015},
month = {Sun Mar 01 00:00:00 EST 2015}
}