An open-source computational and data resource to analyze digital maps of immunopeptidomes
Journal Article
·
· eLife, 4:Article No. e07661
We present a novel proteomics-based workflow and an open source data and computational resource for reproducibly identifying and quantifying HLA-associated peptides at high-throughput. The provided resources support the generation of HLA allele-specific peptide assay libraries consisting of consensus fragment ion spectra and the analysis of quantitative digital maps of HLA peptidomes generated by SWATH mass spectrometry (MS). This is the first community-based study towards the development of a robust platform for the reproducible and quantitative measurement of HLA peptidomes, an essential step towards the design of efficient immunotherapies.
- Research Organization:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 1221455
- Report Number(s):
- PNNL-SA-108494; 48680; 400412000
- Journal Information:
- eLife, 4:Article No. e07661, Journal Name: eLife, 4:Article No. e07661
- Country of Publication:
- United States
- Language:
- English
Similar Records
An open-source computational and data resource to analyze digital maps of immunopeptidomes
A rapid methods development workflow for high-throughput quantitative proteomic applications
Automated “Cells-To-Peptides” Sample Preparation Workflow for High-Throughput, Quantitative Proteomic Assays of Microbes
Journal Article
·
Wed Jul 08 00:00:00 EDT 2015
· eLife
·
OSTI ID:1221455
+22 more
A rapid methods development workflow for high-throughput quantitative proteomic applications
Journal Article
·
Thu Feb 14 00:00:00 EST 2019
· PLoS ONE
·
OSTI ID:1221455
+7 more
Automated “Cells-To-Peptides” Sample Preparation Workflow for High-Throughput, Quantitative Proteomic Assays of Microbes
Journal Article
·
Thu Aug 22 00:00:00 EDT 2019
· Journal of Proteome Research
·
OSTI ID:1221455
+10 more