Heavy ion action on single cells: Cellular inactivation capability of single accelerated heavy ions
- Gesellschaft fuer Schwerionenforschung m.b.H., Darmstadt (Germany)
Heavy ions (HZE-particles) constitute an important part of radiation in space. Although their number is small the high amount of energy transferred by individual particles may cause severe biological effects. Their investigation requires special techniques which were tested by experiments performed at the UNILAC at the GSI (Darmstadt). Diploid yeast was used which is a suitable eucaryotic test system because of its resistance to extreme conditions like dryness and vacuum. Cells were placed on nuclear track detector foils and exposed to ions of different atomic number and energy. To assess the action of one single ion on an individual cell, track parameters and the respective colony forming abilities (CFA) were determined with the help of computer aided image analysis. There is mounting evidence that not only the amount of energy deposited along the particle path, commonly given by the LET, is of importance but also the spatial problem of energy deposition at a submicroscopical scale. It is virtually impossible to investigate track structure effects in detail with whole cell populations and (globally applied) high particle fluences. It is, therefore, necessary to detect the action of simple ions in individual cells. The results show that the biological action depends on atomic number and specific energy of the impinging ions, which can be compared with model calculations of recent track structure models.
- Research Organization:
- National Aeronautics and Space Administration, Moffett Field, CA (United States). Ames Research Center
- OSTI ID:
- 121785
- Report Number(s):
- N-95-32719; NASA-TM-110655; NAS-1.15:110655; CONF-9410388-; TRN: 9532729
- Resource Relation:
- Conference: 12. joint NASA/DARA-DLR life sciences program working group meeting, Moffett Field, CA (United States), 26-27 Oct 1994; Other Information: PBD: 1994; Related Information: Is Part Of Minutes of the 12th Joint NASA/DARA-DLR Life Sciences Program Working Group Meeting; White, R.J.; PB: 234 p.
- Country of Publication:
- United States
- Language:
- English
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