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Title: Radiant energy required for infrared neural stimulation

Abstract

Infrared neural stimulation (INS) has been proposed as an alternative method to electrical stimulation because of its spatial selective stimulation. Independent of the mechanism for INS, to translate the method into a device it is important to determine the energy for stimulation required at the target structure. Custom-designed, flat and angle polished fibers, were used to deliver the photons. By rotating the angle polished fibers, the orientation of the radiation beam in the cochlea could be changed. INS-evoked compound action potentials and single unit responses in the central nucleus of the inferior colliculus (ICC) were recorded. X-ray computed tomography was used to determine the orientation of the optical fiber. Maximum responses were observed when the radiation beam was directed towards the spiral ganglion neurons (SGNs), whereas little responses were seen when the beam was directed towards the basilar membrane. The radiant exposure required at the SGNs to evoke compound action potentials (CAPs) or ICC responses was on average 18.9 ± 12.2 or 10.3 ± 4.9 mJ/cm 2, respectively. For cochlear INS it has been debated whether the radiation directly stimulates the SGNs or evokes a photoacoustic effect. The results support the view that a direct interaction between neurons and radiationmore » dominates the response to INS.« less

Authors:
 [1];  [2];  [1];  [1];  [1];  [3];  [1]
  1. Northwestern Univ., Evanston, IL (United States)
  2. Univ. of Miami, Miami, FL (United States)
  3. Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
USDOE
OSTI Identifier:
1214662
Grant/Contract Number:  
AC02-06CH11357
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Scientific Reports
Additional Journal Information:
Journal Volume: 5; Journal ID: ISSN 2045-2322
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Tan, Xiaodong, Rajguru, Suhrud, Young, Hunter, Xia, Nan, Stock, Stuart R., Xiao, Xianghui, and Richter, Claus-Peter. Radiant energy required for infrared neural stimulation. United States: N. p., 2015. Web. doi:10.1038/srep13273.
Tan, Xiaodong, Rajguru, Suhrud, Young, Hunter, Xia, Nan, Stock, Stuart R., Xiao, Xianghui, & Richter, Claus-Peter. Radiant energy required for infrared neural stimulation. United States. https://doi.org/10.1038/srep13273
Tan, Xiaodong, Rajguru, Suhrud, Young, Hunter, Xia, Nan, Stock, Stuart R., Xiao, Xianghui, and Richter, Claus-Peter. Tue . "Radiant energy required for infrared neural stimulation". United States. https://doi.org/10.1038/srep13273. https://www.osti.gov/servlets/purl/1214662.
@article{osti_1214662,
title = {Radiant energy required for infrared neural stimulation},
author = {Tan, Xiaodong and Rajguru, Suhrud and Young, Hunter and Xia, Nan and Stock, Stuart R. and Xiao, Xianghui and Richter, Claus-Peter},
abstractNote = {Infrared neural stimulation (INS) has been proposed as an alternative method to electrical stimulation because of its spatial selective stimulation. Independent of the mechanism for INS, to translate the method into a device it is important to determine the energy for stimulation required at the target structure. Custom-designed, flat and angle polished fibers, were used to deliver the photons. By rotating the angle polished fibers, the orientation of the radiation beam in the cochlea could be changed. INS-evoked compound action potentials and single unit responses in the central nucleus of the inferior colliculus (ICC) were recorded. X-ray computed tomography was used to determine the orientation of the optical fiber. Maximum responses were observed when the radiation beam was directed towards the spiral ganglion neurons (SGNs), whereas little responses were seen when the beam was directed towards the basilar membrane. The radiant exposure required at the SGNs to evoke compound action potentials (CAPs) or ICC responses was on average 18.9 ± 12.2 or 10.3 ± 4.9 mJ/cm2, respectively. For cochlear INS it has been debated whether the radiation directly stimulates the SGNs or evokes a photoacoustic effect. The results support the view that a direct interaction between neurons and radiation dominates the response to INS.},
doi = {10.1038/srep13273},
url = {https://www.osti.gov/biblio/1214662}, journal = {Scientific Reports},
issn = {2045-2322},
number = ,
volume = 5,
place = {United States},
year = {2015},
month = {8}
}

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Cited by: 9 works
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Works referenced in this record:

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    Works referencing / citing this record:

    Photoacoustic effect invokes auditory response in infrared neuron stimulation
    journal, January 2019


    Vestibular Neuroscience for the Headache Specialist
    journal, May 2019


    Multichannel optrodes for photonic stimulation
    journal, October 2018


    Auditory Neural Activity in Congenitally Deaf Mice Induced by Infrared Neural Stimulation
    journal, January 2018