Linkage between Werner Syndrome Protein and the Mre11 Complex via Nbs1
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May 2004 |
WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations
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May 2010 |
Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
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February 2010 |
Increased Chemotherapeutic Activity of Camptothecin in Cancer Cells by siRNA-Induced Silencing of WRN Helicase
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January 2007 |
Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling
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February 2013 |
Cytogenet Genome Res of Werner’s syndrome cultured skin fibroblasts: variegated translocation mosaicism
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January 1981 |
Werner's Syndrome Protein Is Required for Correct Recovery after Replication Arrest and DNA Damage Induced in S-Phase of Cell Cycle
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August 2001 |
Identification of a Coiled Coil in Werner Syndrome Protein That Facilitates Multimerization and Promotes Exonuclease Processivity
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August 2010 |
Werner syndrome protein associates with γH2AX in a manner that depends upon Nbs1
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January 2005 |
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
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April 2005 |
Inhibition of Homologous Recombination in Human Cells by Targeting RAD51 Recombinase
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March 2012 |
The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome
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June 2011 |
WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair
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August 2003 |
A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
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October 1998 |
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest
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December 2006 |
The Werner syndrome protein is a DNA helicase
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September 1997 |
Werner syndrome protein, the MRE11 complex and ATR: menage-à-trois in guarding genome stability during DNA replication?: Hypothesis
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February 2004 |
Topoisomerase I poisoning results in PARP-mediated replication fork reversal
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March 2012 |
Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11
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June 2011 |
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing
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April 2006 |
DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities
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January 2014 |
Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11
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May 2011 |
Novel pro- and anti-recombination activities of the Bloom's syndrome helicase
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December 2007 |
Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines
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October 1992 |
Counting RAD51 proteins disassembling from nucleoprotein filaments under tension
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December 2008 |
A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2
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July 2012 |
The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest
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March 2008 |
A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex
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January 2008 |
Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis
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October 2010 |
WRN helicase regulates the ATR–CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I–DNA covalent complexes
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December 2011 |
Mutator phenotype of Werner syndrome is characterized by extensive deletions.
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August 1989 |
Werner syndrome diploid fibroblasts are sensitive to 4‐nitroquinoline‐N‐oxide and 8‐methoxypsoralen: implications for the disease phenotype
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March 2002 |
WRN Interacts Physically and Functionally with the Recombination Mediator Protein RAD52
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September 2003 |
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition
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February 2013 |
The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease
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October 1998 |
The Werner Syndrome Protein Is Distinguished from the Bloom Syndrome Protein by Its Capacity to Tightly Bind Diverse DNA Structures
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January 2012 |
Homologous recombination repair is regulated by domains at the N- and C-terminus of NBS1 and is dissociated with ATM functions
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March 2007 |
ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery
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August 2010 |
DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs
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May 2010 |
Defective Mre11-dependent Activation of Chk2 by Ataxia Telangiectasia Mutated in Colorectal Carcinoma Cells in Response to Replication-dependent DNA Double Strand Breaks
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October 2006 |
Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase
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February 1999 |
Werner Syndrome Protein Contains Three Structure-specific DNA Binding Domains
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December 2003 |
Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination
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March 2008 |
Pathways of mammalian replication fork restart
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September 2010 |
Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background
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May 2000 |
Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases
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June 2010 |
Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis
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January 2010 |
WRN participates in translesion synthesis pathway through interaction with NBS1
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June 2010 |
Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing
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December 1997 |
Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51: Nuclear foci formation of Werner helicase
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May 2001 |
The Essential Functions of Human Rad51 Are Independent of ATP Hydrolysis
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October 1999 |
Accumulation of Werner protein at DNA double-strand breaks in human cells
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September 2005 |
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments
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December 2007 |
Rad51 overexpression rescues radiation resistance in BRCA2-defective cancer cells
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February 2009 |
Ku complex interacts with and stimulates the Werner protein
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April 2000 |