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Title: Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling

Abstract

A non-aqueous single pot synthesis of [.sup.18F]SFB is set forth. The [.sup.18F]SFB produced with this method is then used, for example, to label a peptide or an engineered antibody fragment (diabody) targeting human epidermal growth factor receptor 2 (HER2) as representative examples of labeled compounds for use as an injectable composition to locate abnormal tissue, specifically tumors within an animal or human using a PET scan.

Inventors:
;
Publication Date:
Research Org.:
The Regents Of The University Of California, Oakland, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1207285
Patent Number(s):
9,096,647
Application Number:
13/924,397
Assignee:
The Regents Of The University Of California (Oakland, CA) CHO
DOE Contract Number:  
FG02-06ER64249
Resource Type:
Patent
Resource Relation:
Patent File Date: 2013 Jun 21
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats

Olma, Sebastian, and Shen, Clifton Kwang-Fu. Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling. United States: N. p., 2015. Web.
Olma, Sebastian, & Shen, Clifton Kwang-Fu. Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling. United States.
Olma, Sebastian, and Shen, Clifton Kwang-Fu. Tue . "Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling". United States. doi:. https://www.osti.gov/servlets/purl/1207285.
@article{osti_1207285,
title = {Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling},
author = {Olma, Sebastian and Shen, Clifton Kwang-Fu},
abstractNote = {A non-aqueous single pot synthesis of [.sup.18F]SFB is set forth. The [.sup.18F]SFB produced with this method is then used, for example, to label a peptide or an engineered antibody fragment (diabody) targeting human epidermal growth factor receptor 2 (HER2) as representative examples of labeled compounds for use as an injectable composition to locate abnormal tissue, specifically tumors within an animal or human using a PET scan.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 04 00:00:00 EDT 2015},
month = {Tue Aug 04 00:00:00 EDT 2015}
}

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Works referenced in this record:

Radiolabelling of isopeptide Nε-(γ-glutamyl)-l-lysine by conjugation with N-succinimidyl-4-[18F]fluorobenzoate
journal, July 2003