Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling
Patent
·
OSTI ID:1207285
A non-aqueous single pot synthesis of [.sup.18F]SFB is set forth. The [.sup.18F]SFB produced with this method is then used, for example, to label a peptide or an engineered antibody fragment (diabody) targeting human epidermal growth factor receptor 2 (HER2) as representative examples of labeled compounds for use as an injectable composition to locate abnormal tissue, specifically tumors within an animal or human using a PET scan.
- Research Organization:
- The Regents Of The University Of California, Oakland, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG02-06ER64249
- Assignee:
- The Regents Of The University Of California (Oakland, CA)
- Patent Number(s):
- 9,096,647
- Application Number:
- 13/924,397
- OSTI ID:
- 1207285
- Country of Publication:
- United States
- Language:
- English
Facile synthesis ofN-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) for protein labeling
|
journal | January 2008 |
Recent progress in fluorine-18 labelled peptide radiopharmaceuticals
|
journal | April 2001 |
Radiolabelling of isopeptide Nε-(γ-glutamyl)-l-lysine by conjugation with N-succinimidyl-4-[18F]fluorobenzoate
|
journal | July 2003 |
Synthesis of Sildenafil Analogues from Anacardic Acid and Their Phosphodiesterase-5 Inhibition
|
journal | December 2002 |
Similar Records
Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling
F-18 Labeled Diabody-Luciferase Fusion Proteins for Optical-ImmunoPET
89Zr-Radiolabeled Trastuzumab Imaging in Orthotopic and Metastatic Breast Tumors
Patent
·
2013
·
OSTI ID:1087870
F-18 Labeled Diabody-Luciferase Fusion Proteins for Optical-ImmunoPET
Technical Report
·
2013
·
OSTI ID:1060194
89Zr-Radiolabeled Trastuzumab Imaging in Orthotopic and Metastatic Breast Tumors
Journal Article
·
2012
· Pharmaceuticals
·
OSTI ID:1629737