Cellulase variants
Patent
·
OSTI ID:1193384
This invention provides novel variant cellulolytic enzymes having improved activity and/or stability. In certain embodiments the variant cellulotyic enzymes comprise a glycoside hydrolase with or comprising a substitution at one or more positions corresponding to one or more of residues F64, A226, and/or E246 in Thermobifida fusca Cel9A enzyme. In certain embodiments the glycoside hydrolase is a variant of a family 9 glycoside hydrolase. In certain embodiments the glycoside hydrolase is a variant of a theme B family 9 glycoside hydrolase.
- Research Organization:
- Novozymes, A/S, Bagsvaerd (Denmark)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- SC0002302
- Assignee:
- Novozymes, A/S (Bagsvaerd, DK)
- Patent Number(s):
- 9,080,162
- Application Number:
- 14/111,321
- OSTI ID:
- 1193384
- Resource Relation:
- Patent File Date: 2012 Apr 11
- Country of Publication:
- United States
- Language:
- English
Increased Crystalline Cellulose Activity via Combinations of Amino Acid Changes in the Family 9 Catalytic Domain and Family 3c Cellulose Binding Module of Thermobifida fusca Cel9A
|
journal | February 2010 |
Integration of Computer Modeling and Initial Studies of Site-Directed Mutagenesis to Improve Cellulase Activity on Cel9A from <I>Thermobifida fusca </I>
|
journal | January 2004 |
Kinetic Studies of Thermobifida fusca Cel9A Active Site Mutant Enzymes
|
journal | August 2004 |
Processivity, Substrate Binding, and Mechanism of Cellulose Hydrolysis by Thermobifida fusca Cel9A
|
journal | March 2007 |
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