The utility of protein and mRNA correlation

Journal Article · Thu Jan 01 00:00:00 EST 2015 · Trends in Biochemical Sciences, 40(1):1-3

DOI:https://doi.org/10.1016/j.tibs.2014.10.010· OSTI ID:1188894

Payne, Samuel H.

Transcriptomic, proteomic and metabolomic measurements are revolutionizing the way we model and predict cellular behavior, and multi-omic comparisons are being published with increased regularity. Some have expected a trivial and predictable correlation between mRNA and protein; however the manifest complexity of biological regulation suggests a more nuanced relationship. Indeed, observing this lack of strict correlation provides clues for new research topics, and has the potential for transformative biological insight.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 1188894
• Report Number(s): PNNL-SA-106549; KP1601010
• Journal Information: Trends in Biochemical Sciences, 40(1):1-3, Journal Name: Trends in Biochemical Sciences, 40(1):1-3
• Country of Publication: United States
• Language: English