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Title: The utility of protein and mRNA correlation

Abstract

Transcriptomic, proteomic and metabolomic measurements are revolutionizing the way we model and predict cellular behavior, and multi-omic comparisons are being published with increased regularity. Some have expected a trivial and predictable correlation between mRNA and protein; however the manifest complexity of biological regulation suggests a more nuanced relationship. Indeed, observing this lack of strict correlation provides clues for new research topics, and has the potential for transformative biological insight.

Authors:
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1188894
Report Number(s):
PNNL-SA-106549
KP1601010
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Resource Relation:
Journal Name: Trends in Biochemical Sciences, 40(1):1-3
Country of Publication:
United States
Language:
English

Citation Formats

Payne, Samuel H. The utility of protein and mRNA correlation. United States: N. p., 2015. Web. doi:10.1016/j.tibs.2014.10.010.
Payne, Samuel H. The utility of protein and mRNA correlation. United States. doi:10.1016/j.tibs.2014.10.010.
Payne, Samuel H. Thu . "The utility of protein and mRNA correlation". United States. doi:10.1016/j.tibs.2014.10.010.
@article{osti_1188894,
title = {The utility of protein and mRNA correlation},
author = {Payne, Samuel H.},
abstractNote = {Transcriptomic, proteomic and metabolomic measurements are revolutionizing the way we model and predict cellular behavior, and multi-omic comparisons are being published with increased regularity. Some have expected a trivial and predictable correlation between mRNA and protein; however the manifest complexity of biological regulation suggests a more nuanced relationship. Indeed, observing this lack of strict correlation provides clues for new research topics, and has the potential for transformative biological insight.},
doi = {10.1016/j.tibs.2014.10.010},
journal = {Trends in Biochemical Sciences, 40(1):1-3},
number = ,
volume = ,
place = {United States},
year = {Thu Jan 01 00:00:00 EST 2015},
month = {Thu Jan 01 00:00:00 EST 2015}
}