Uses of monoclonial antibody 8H9

Cheung, Nai-Kong V.

Uses of monoclonial antibody 8H9

Patent · 23 June 2015

OSTI ID:1185299

Cheung, Nai-Kong V.

This invention provides an antibody that binds the same antigen as that of monoclonal antibody 8H9, wherein the heavy chain CDR (Complementary Determining Region)1 comprises NYDIN, heavy chain CDR2 comprises WIFPGDGSTQY, heavy chain CDR3 comprises QTTATWFAY, and the light chain CDR1 comprises RASQSISDYLH, light chain CDR2 comprises YASQSIS, and light chain CDR3 comprises QNGHSFPLT. In another embodiment, there is provided a polypeptide that binds the same antigen as that of monoclonal antibody 8H9, wherein the polypeptide comprises NYDIN, WIFPGDGSTQY, QTTATWFAY, RASQSISDYLH, YASQSIS, and QNGHSFPLT.

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Research Organization:: Sloan-Kettering Inst. for Cancer Research, New York, NY (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-93ER61658

Assignee:: Sloan-Kettering Institute for Cancer Research (New York, NY)

Patent Number(s):: 9,062,110

Application Number:: 13/858,234

OSTI ID:: 1185299

Country of Publication:: United States

Language:: English

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