Monoamine oxidase: Radiotracer chemistry and human studies

Fowler, Joanna S.; Logan, Jean; Shumay, Elena; Alia-Klein, Nelly; Wang, Gene-Jack; Volkow, Nora D.

doi:10.1002/jlcr.3247

Title: Monoamine oxidase: Radiotracer chemistry and human studies

Journal Article · Sun Mar 01 00:00:00 EST 2015 · Journal of Labelled Compounds and Radiopharmaceuticals

DOI:https://doi.org/10.1002/jlcr.3247· OSTI ID:1183290

Fowler, Joanna S. ^[1]; Logan, Jean ^[2]; Shumay, Elena ^[3]; Alia-Klein, Nelly ^[4]; Wang, Gene-Jack ^[3]; Volkow, Nora D. ^[5]

Brookhaven National Lab. (BNL), Upton, NY (United States)
New York Univ., Langone Medical Center, New York, NY (United States)
National Inst. on Alcohol Abuse and Alcoholism, National Inst. of Health, Betheseda, MD (United States)
Mount Sinai School of Medicine, New York, NY (United States)
National Inst. on Alcohol Abuse and Alcoholism, National Inst. of Health, Betheseda, MD (United States); National Inst. on Drug Abuse, National Inst. of Health, Bethesda, MD (United States)

Monoamine oxidase (MAO) oxidizes amines from both endogenous and exogenous sources thereby regulating the concentration of neurotransmitter amines such as serot onin, norepinephrine and dopamine as well as many xenobiotics. MAO inhibitor drugs are used in the treatment of Parkinson’s disease and in depression stimulating the development of radiotracer tools to probe the role of MAO in normal human biology and in disease. Over the past 30 since the first radiotracers were developed and the first PET images of MAO in humans were carried out, PET studies of brain MAO in healthy volunteers and in patients have identified different variables which have contributed to different MAO levels in brain and in peripheral organs. MAO radiotracers and PET have also been used to study the current and developing MAO inhibitor drugs including the selection of doses for clinical trials. In this article, we describe (1) the development of MAO radiotracers; (2) human studies including the relationship of brain MAO levels to genotype, personality, neurological and psychiatric disorders; (3) examples of the use of MAO radiotracers in drug research and development. We will conclude with outstanding needs to improve the radiotracers which are currently used and possible new applications.

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC00112704

OSTI ID:: 1183290

Report Number(s):: BNL-107778-2015-JA; R&D Project: MO-085; KP1602010

Journal Information:: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 58, Issue 3; ISSN 0362-4803

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 40 works

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Monoamine oxidase B activity is increased in human gliomas Gabilondo, Ane M.; Hostalot, Cristina; Garibi, Jesús M. Neurochemistry International, Vol. 52, Issue 1-2 https://doi.org/10.1016/j.neuint.2007.05.015	journal	January 2008
Suicide enzyme inactivators Abeles, Robert H.; Maycock, Alan L. Accounts of Chemical Research, Vol. 9, Issue 9 https://doi.org/10.1021/ar50105a001	journal	September 1976
Comparison of the binding of the irreversible monoamine oxidase tracers, [11C]clorgyline and [11C]l-deprenyl in brain and peripheral organs in humans Fowler, Joanna S.; Logan, Jean; Wang, Gene-Jack Nuclear Medicine and Biology, Vol. 31, Issue 3 https://doi.org/10.1016/j.nucmedbio.2003.10.003	journal	April 2004

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Kinetics, mechanism, and inhibition of monoamine oxidase Ramsay, Rona R.; Albreht, Alen Journal of Neural Transmission, Vol. 125, Issue 11 https://doi.org/10.1007/s00702-018-1861-9	journal	March 2018
The monoamine oxidase inhibition properties of C6- and N1-substituted 3-methyl-3,4-dihydroquinazolin-2(1H)-one derivatives Marais, Lereze; Petzer, Anél; Petzer, Jacobus P. Molecular Diversity, Vol. 24, Issue 2 https://doi.org/10.1007/s11030-019-09960-5	journal	May 2019
Neuroinflammation in Neurodegenerative Disorders—a Review Schain, Martin; Kreisl, William Charles Current Neurology and Neuroscience Reports, Vol. 17, Issue 3 https://doi.org/10.1007/s11910-017-0733-2	journal	March 2017
Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity Doboszewska, Urszula; Wlaź, Piotr; Nowak, Gabriel Neural Plasticity, Vol. 2017 https://doi.org/10.1155/2017/3682752	journal	January 2017
Neuroimaging-pathological correlations of [18F]THK5351 PET in progressive supranuclear palsy Ishiki, Aiko; Harada, Ryuichi; Kai, Hideaki Acta Neuropathologica Communications, Vol. 6, Issue 1 https://doi.org/10.1186/s40478-018-0556-7	journal	June 2018
Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration Ramsay, Rona R.; Majekova, Magdalena; Medina, Milagros Frontiers in Neuroscience, Vol. 10 https://doi.org/10.3389/fnins.2016.00375	journal	August 2016
Assessment of Enzyme Inhibition: A Review with Examples from the Development of Monoamine Oxidase and Cholinesterase Inhibitory Drugs Ramsay, Rona; Tipton, Keith Molecules, Vol. 22, Issue 7 https://doi.org/10.3390/molecules22071192	journal	July 2017
Assessment of Enzyme Inhibition: A Review with Examples from the Development of Monoamine Oxidase and Cholinesterase Inhibitory Drugs Ramsay, Rona R.; Tipton, Keith F. Molecules https://doi.org/10.20944/preprints201707.0019.v1	journal	July 2017

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