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Title: Micro-fluidic partitioning between polymeric sheets for chemical amplification and processing

Patent ·
OSTI ID:1182597

A system for fluid partitioning for chemical amplification or other chemical processing or separations of a sample, comprising a first dispenser of a first polymeric sheet, wherein the first polymeric sheet contains chambers; a second dispenser of a second polymeric sheet wherein the first dispenser and the second dispenser are positioned so that the first polymeric sheet and the second polymeric sheet become parallel; a dispenser of the fluid positioned to dispense the fluid between the first polymeric sheet and the second polymeric sheet; and a seal unit that seals the first polymeric sheet and the second polymeric sheet together thereby sealing the sample between the first polymeric sheet and the second polymeric sheet and partitioning the fluid for chemical amplification or other chemical processing or separations.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC52-07NA27344
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA)
Patent Number(s):
9,038,689
Application Number:
13/480,274
OSTI ID:
1182597
Country of Publication:
United States
Language:
English

References (6)

High speed form, fill and seal pouch packaging machine patent July 2004
Chemical amplification based on fluid partitioning patent May 2006
Polymer-based platform for microfluidic systems patent October 2009
Chemical amplification based on fluid partitioning in an immiscible liquid patent September 2010
Microfluidic reaction apparatus for high throughput screening patent October 2010
Microfluidic device and methods of using same patent November 2010