Producing dicarboxylic acids using polyketide synthases

Katz, Leonard; Fortman, Jeffrey L.; Keasling, Jay D.

Title: Producing dicarboxylic acids using polyketide synthases

Patent · Tue May 26 00:00:00 EDT 2015

OSTI ID:1182574

Katz, Leonard; Fortman, Jeffrey L.; Keasling, Jay D.

The present invention provides for a polyketide synthase (PKS) capable of synthesizing a dicarboxylic acid (diacid). Such diacids include diketide-diacids and triketide-diacids. The invention includes recombinant nucleic acid encoding the PKS, and host cells comprising the PKS. The invention also includes methods for producing the diacids.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 9,040,282

Application Number:: 14/038,488

OSTI ID:: 1182574

Country of Publication:: United States

Language:: English

References (10)

Recombinant production of novel polyketides Khosla, Chaitan; Hopwood, David A.; Ebert-Khosla, Suzanne https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5672491 US Patent Document 5,672,491	patent	September 1997
Recombinant combinatorial genetic library for the production of novel polyketides Khosla, Chaitan; Hopwood, David A.; Ebert-Khosla, Suzanne https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5712146 US Patent Document 5,712,146	patent	January 1998
Recombinant production of novel polyketides Khosla, Chaitan; Hopwood, David A.; Ebert-Khosla, Suzanne https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5830750 US Patent Document 5,830,750	patent	November 1998
Recombinant production of novel polyketides Khosla, Chaitan; Hopwood, David A.; Ebert-Khosla, Susanne https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5843718 US Patent Document 5,843,718	patent	December 1998
Recombinant methods and materials for producing epothilones C and D Julien, Bryan; Katz, Leonard; Khosla, Chaitan https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6303342 US Patent Document 6,303,342	patent	October 2001
Polyketides and their synthesis Leadlay, Peter Francis; Staunton, James; Cortes, Jesus https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7198922 US Patent Document 7,198,922	patent	April 2007
A chain initiation factor common to both modular and aromatic polyketide synthases Bisang, Christian; Long, Paul F.; Corte´s, Jesús Nature, Vol. 401, Issue 6752 https://doi.org/10.1038/46829	journal	September 1999
Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units Heathcote, Michelle L.; Staunton, James; Leadlay, Peter F. Chemistry & Biology, Vol. 8, Issue 2, p. 207-220 https://doi.org/10.1016/S1074-5521(01)00002-3	journal	February 2001
Precursor-Directed Biosynthesis of Erythromycin Analogs by an Engineered Polyketide Synthase Jacobsen, J. R. Science, Vol. 277, Issue 5324 https://doi.org/10.1126/science.277.5324.367	journal	July 1997
Synthesis of C₅-dicarboxylic acids from C₂-units involving crotonyl-CoA carboxylase/reductase: The ethylmalonyl-CoA pathway Erb, T. J.; Berg, I. A.; Brecht, V. Proceedings of the National Academy of Sciences, Vol. 104, Issue 25, p. 10631-10636 https://doi.org/10.1073/pnas.0702791104	journal	June 2007

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Title: Producing dicarboxylic acids using polyketide synthases

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