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Title: Producing dicarboxylic acids using polyketide synthases

Abstract

The present invention provides for a polyketide synthase (PKS) capable of synthesizing a dicarboxylic acid (diacid). Such diacids include diketide-diacids and triketide-diacids. The invention includes recombinant nucleic acid encoding the PKS, and host cells comprising the PKS. The invention also includes methods for producing the diacids.

Inventors:
; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1182574
Patent Number(s):
9,040,282
Application Number:
14/038,488
Assignee:
The Regents of the University of California (Oakland, CA) CHO
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Katz, Leonard, Fortman, Jeffrey L., and Keasling, Jay D.. Producing dicarboxylic acids using polyketide synthases. United States: N. p., 2015. Web.
Katz, Leonard, Fortman, Jeffrey L., & Keasling, Jay D.. Producing dicarboxylic acids using polyketide synthases. United States.
Katz, Leonard, Fortman, Jeffrey L., and Keasling, Jay D.. Tue . "Producing dicarboxylic acids using polyketide synthases". United States. doi:. https://www.osti.gov/servlets/purl/1182574.
@article{osti_1182574,
title = {Producing dicarboxylic acids using polyketide synthases},
author = {Katz, Leonard and Fortman, Jeffrey L. and Keasling, Jay D.},
abstractNote = {The present invention provides for a polyketide synthase (PKS) capable of synthesizing a dicarboxylic acid (diacid). Such diacids include diketide-diacids and triketide-diacids. The invention includes recombinant nucleic acid encoding the PKS, and host cells comprising the PKS. The invention also includes methods for producing the diacids.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 26 00:00:00 EDT 2015},
month = {Tue May 26 00:00:00 EDT 2015}
}

Patent:

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Works referenced in this record:

Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units
journal, February 2001


Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: The ethylmalonyl-CoA pathway
journal, June 2007

  • Erb, T. J.; Berg, I. A.; Brecht, V.
  • Proceedings of the National Academy of Sciences, Vol. 104, Issue 25, p. 10631-10636
  • DOI: 10.1073/pnas.0702791104