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Title: Systematic identification of genes and transduction pathways involved in radio-adaptive response

Abstract

Low doses of radiation have been shown to protect against the biological effects of later exposure to toxic levels of radiation. In this study, we propose to identify the molecular mechanisms of this adaptive response by systematically identifying the genes that play a role in radio-protection. In the original proposal, a human cell line that is well-documented to exhibit the radio-adaptive effect was to be used. In this revised study plan, we will use a mouse model, C57BL/6, which has also been well investigated for radio-adaptation. The goal of the proposed study is to enhance our understanding of cellular responses to low doses of radiation exposure at the molecular level.

Authors:
 [1]
  1. NASA Johnson Space Center, Houston, TX (United States)
Publication Date:
Research Org.:
NASA Johnson Space Center, Houston, TX (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
Contributing Org.:
NASA
OSTI Identifier:
1182410
DOE Contract Number:  
SC0002497
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; Low dose radiation effects

Citation Formats

Wu, Honglu. Systematic identification of genes and transduction pathways involved in radio-adaptive response. United States: N. p., 2015. Web.
Wu, Honglu. Systematic identification of genes and transduction pathways involved in radio-adaptive response. United States.
Wu, Honglu. Fri . "Systematic identification of genes and transduction pathways involved in radio-adaptive response". United States.
@article{osti_1182410,
title = {Systematic identification of genes and transduction pathways involved in radio-adaptive response},
author = {Wu, Honglu},
abstractNote = {Low doses of radiation have been shown to protect against the biological effects of later exposure to toxic levels of radiation. In this study, we propose to identify the molecular mechanisms of this adaptive response by systematically identifying the genes that play a role in radio-protection. In the original proposal, a human cell line that is well-documented to exhibit the radio-adaptive effect was to be used. In this revised study plan, we will use a mouse model, C57BL/6, which has also been well investigated for radio-adaptation. The goal of the proposed study is to enhance our understanding of cellular responses to low doses of radiation exposure at the molecular level.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {5}
}

Technical Report:
Other availability
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