Human Recombinant Phosphodiesterase 4B2B Binds ( R )-Rolipram at a Single Site with Two Affinities
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November 1997 |
Comparison of Recombinant Human PDE4 Isoforms
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June 1998 |
A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.
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October 1993 |
PRKAR1A and PDE4D Mutations Cause Acrodysostosis but Two Distinct Syndromes with or without GPCR-Signaling Hormone Resistance
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December 2012 |
The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579
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February 1999 |
Phosphorylation and Activation of a cAMP-specific Phosphodiesterase by the cAMP-dependent Protein Kinase: INVOLVEMENT OF SERINE 54 IN THE ENZYME ACTIVATION
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journal
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July 1996 |
Recombinant Expression of a Type IV, cAMP-Specific Phosphodiesterase: Characterization and Structure−Function Studies of Deletion Mutants †
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journal
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March 1997 |
The Human Cyclic AMP-specific Phosphodiesterase PDE-46 (HSPDE4A4B) Expressed in Transfected COS7 Cells Occurs as Both Particulate and Cytosolic Species That Exhibit Distinct Kinetics of Inhibition by the Antidepressant Rolipram
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December 1996 |
Crystal structure of phosphodiesterase 4D and inhibitor complex 1
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September 2002 |
The regulatory tandem domains of human phosphodiesterases 1 and 4 regulate a cyanobacterial adenylyl cyclase
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August 2012 |
UCR1 and UCR2 Domains Unique to the cAMP-specific Phosphodiesterase Family Form a Discrete Module via Electrostatic Interactions
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March 2000 |
Probability-based protein identification by searching sequence databases using mass spectrometry data
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December 1999 |
Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins
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February 2010 |
Phosphodiesterases in the CNS: targets for drug development
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August 2006 |
Dimerization of the Type 4 cAMP-specific Phosphodiesterases Is Mediated by the Upstream Conserved Regions (UCRs)
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August 2002 |
Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode
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July 2009 |
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
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December 1998 |
Exome Sequencing Identifies PDE4D Mutations in Acrodysostosis
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April 2012 |
Exome Sequencing Identifies PDE4D Mutations as Another Cause of Acrodysostosis
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April 2012 |
Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety
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December 2009 |
Activation of the cAMP-specific Phosphodiesterase PDE4D3 by Phosphorylation: IDENTIFICATION AND FUNCTION OF AN INHIBITORY DOMAIN
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July 1999 |
The CCP4 suite programs for protein crystallography
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September 1994 |
Atomic Structure of PDE4: Insights into Phosphodiesterase Mechanism and Specificity
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June 2000 |
Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1): PKA phosphorylation of PDE4 cAMP phosphodiesterases
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June 2002 |
Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors
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journal
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November 2007 |
Phosphodiesterases as Drug Targets
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book
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January 2011 |
Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases: Erk phosphorylation of PDE4 isoenzymes
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journal
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October 2000 |
Cyclic nucleotide research — still expanding after half a century
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journal
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September 2002 |
Identification of Novel Mutations Confirms Pde4d as a Major Gene Causing Acrodysostosis : HUMAN MUTATION
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November 2012 |
Features and development of Coot
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March 2010 |
Keynote review: Phosphodiesterase-4 as a therapeutic target
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November 2005 |
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization
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journal
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February 2003 |
Complexity and Diversity of Mammalian Adenylyl Cyclases
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journal
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April 1996 |
Putting the lid on phosphodiesterase 4
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journal
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January 2010 |
Cyclic Nucleotide-Gated Channels: Molecular Mechanisms of Activation
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journal
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April 1999 |
Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases
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journal
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December 2004 |
The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s)
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April 2014 |
Data processing and analysis with the autoPROC toolbox
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journal
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March 2011 |
Physiological concentrations of purines and pyrimidines
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journal
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January 1994 |
Heterologous Expression and Purification of Recombinant Rolipram-Sensitive Cyclic AMP-Specific Phosphodiesterases
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journal
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January 1998 |
Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct
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October 2009 |
Different mutations in PDE4D associated with developmental disorders with mirror phenotypes
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November 2013 |
Structural basis for the design of selective phosphodiesterase 4B inhibitors
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journal
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March 2014 |
Phaser crystallographic software
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journal
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July 2007 |
Results of a Phase II Study of the Antidepressant Effect of Rolipram
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journal
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November 1984 |
Characterization of the structure of a low Km, rolipram-sensitive cAMP phosphodiesterase. Mapping of the catalytic domain.
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journal
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September 1992 |