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Title: Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated β-lactam antibiotic

Abstract

We have determined a 1.18 Å resolution X-ray crystal structure of a novel ruthenocenyle-6-aminopenicillinic acid in complex with CTX-M β-lactamase, showing unprecedented details of interactions between ruthenocene and protein. As the first product complex with an intact catalytic serine, the structure also offers insights into β-lactamase catalysis and inhibitor design.

Authors:
 [1];  [2];  [1];  [3];  [3];  [2];  [1]
  1. Univ. of South Florida, Tampa, FL (United States). Dept. of PMolecular Medicine
  2. Univ. of Lodz (Poland). Dept. of Organic Chemistry
  3. National Inst. of Public Health - National Inst. of Hygiene (NIPH-NIH), Warsaw (Poland)
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
National Institutes of Health (NIH); USDOE
OSTI Identifier:
1178850
Grant/Contract Number:
W-31-109-Eng-38; DEC-2013/11/B/ST5/00997
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
ChemComm
Additional Journal Information:
Journal Volume: 51; Journal Issue: 28; Journal ID: ISSN 1359-7345
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
ENGLISH
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Lewandowski, Eric M., Skiba, Joanna, Torelli, Nicholas J., Rajnisz, Aleksandra, Solecka, Jolanta, Kowalski, Konrad, and Chen, Yu. Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated β-lactam antibiotic. United States: N. p., 2015. Web. doi:10.1039/C5CC00904A.
Lewandowski, Eric M., Skiba, Joanna, Torelli, Nicholas J., Rajnisz, Aleksandra, Solecka, Jolanta, Kowalski, Konrad, & Chen, Yu. Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated β-lactam antibiotic. United States. doi:10.1039/C5CC00904A.
Lewandowski, Eric M., Skiba, Joanna, Torelli, Nicholas J., Rajnisz, Aleksandra, Solecka, Jolanta, Kowalski, Konrad, and Chen, Yu. Mon . "Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated β-lactam antibiotic". United States. doi:10.1039/C5CC00904A. https://www.osti.gov/servlets/purl/1178850.
@article{osti_1178850,
title = {Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated β-lactam antibiotic},
author = {Lewandowski, Eric M. and Skiba, Joanna and Torelli, Nicholas J. and Rajnisz, Aleksandra and Solecka, Jolanta and Kowalski, Konrad and Chen, Yu},
abstractNote = {We have determined a 1.18 Å resolution X-ray crystal structure of a novel ruthenocenyle-6-aminopenicillinic acid in complex with CTX-M β-lactamase, showing unprecedented details of interactions between ruthenocene and protein. As the first product complex with an intact catalytic serine, the structure also offers insights into β-lactamase catalysis and inhibitor design.},
doi = {10.1039/C5CC00904A},
journal = {ChemComm},
number = 28,
volume = 51,
place = {United States},
year = {Mon Mar 02 00:00:00 EST 2015},
month = {Mon Mar 02 00:00:00 EST 2015}
}

Journal Article:
Free Publicly Available Full Text
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Cited by: 11 works
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