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Title: Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures

Authors:
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  1. (Lilly)
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
INDUSTRY
OSTI Identifier:
1178825
Resource Type:
Journal Article
Resource Relation:
Journal Name: J. Med. Chem.; Journal Volume: 58; Journal Issue: (4) ; 02, 2015
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Monn, James A., Prieto, Lourdes, Taboada, Lorena, Pedregal, Concepcion, Hao, Junliang, Reinhard, Matt R., Henry, Steven S., Goldsmith, Paul J., Beadle, Christopher D., Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K., Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A., Wang, Xushan, Carter, Joan H., Xiang, Chuanxi, Catlow, John T., Swanson, Steven, Sanger, Helen, Broad, Lisa M., Johnson, Michael P., Knopp, Kelly L., Simmons, Rosa M.A., Johnson, Bryan G., Shaw, David B., and McKinzie, David L.. Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures. United States: N. p., 2015. Web. doi:10.1021/jm501612y.
Monn, James A., Prieto, Lourdes, Taboada, Lorena, Pedregal, Concepcion, Hao, Junliang, Reinhard, Matt R., Henry, Steven S., Goldsmith, Paul J., Beadle, Christopher D., Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K., Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A., Wang, Xushan, Carter, Joan H., Xiang, Chuanxi, Catlow, John T., Swanson, Steven, Sanger, Helen, Broad, Lisa M., Johnson, Michael P., Knopp, Kelly L., Simmons, Rosa M.A., Johnson, Bryan G., Shaw, David B., & McKinzie, David L.. Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures. United States. doi:10.1021/jm501612y.
Monn, James A., Prieto, Lourdes, Taboada, Lorena, Pedregal, Concepcion, Hao, Junliang, Reinhard, Matt R., Henry, Steven S., Goldsmith, Paul J., Beadle, Christopher D., Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K., Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A., Wang, Xushan, Carter, Joan H., Xiang, Chuanxi, Catlow, John T., Swanson, Steven, Sanger, Helen, Broad, Lisa M., Johnson, Michael P., Knopp, Kelly L., Simmons, Rosa M.A., Johnson, Bryan G., Shaw, David B., and McKinzie, David L.. Thu . "Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures". United States. doi:10.1021/jm501612y.
@article{osti_1178825,
title = {Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures},
author = {Monn, James A. and Prieto, Lourdes and Taboada, Lorena and Pedregal, Concepcion and Hao, Junliang and Reinhard, Matt R. and Henry, Steven S. and Goldsmith, Paul J. and Beadle, Christopher D. and Walton, Lesley and Man, Teresa and Rudyk, Helene and Clark, Barry and Tupper, David and Baker, S. Richard and Lamas, Carlos and Montero, Carlos and Marcos, Alicia and Blanco, Jaime and Bures, Mark and Clawson, David K. and Atwell, Shane and Lu, Frances and Wang, Jing and Russell, Marijane and Heinz, Beverly A. and Wang, Xushan and Carter, Joan H. and Xiang, Chuanxi and Catlow, John T. and Swanson, Steven and Sanger, Helen and Broad, Lisa M. and Johnson, Michael P. and Knopp, Kelly L. and Simmons, Rosa M.A. and Johnson, Bryan G. and Shaw, David B. and McKinzie, David L.},
abstractNote = {},
doi = {10.1021/jm501612y},
journal = {J. Med. Chem.},
number = (4) ; 02, 2015,
volume = 58,
place = {United States},
year = {Thu Feb 26 00:00:00 EST 2015},
month = {Thu Feb 26 00:00:00 EST 2015}
}