Volume-labeled nanoparticles and methods of preparation

Wang, Wei; Gu, Baohua; Retterer, Scott T; Doktycz, Mitchel J

Title: Volume-labeled nanoparticles and methods of preparation

Patent · Tue Apr 21 00:00:00 EDT 2015

OSTI ID:1178265

Wang, Wei; Gu, Baohua; Retterer, Scott T; Doktycz, Mitchel J

Compositions comprising nanosized objects (i.e., nanoparticles) in which at least one observable marker, such as a radioisotope or fluorophore, is incorporated within the nanosized object. The nanosized objects include, for example, metal or semi-metal oxide (e.g., silica), quantum dot, noble metal, magnetic metal oxide, organic polymer, metal salt, and core-shell nanoparticles, wherein the label is incorporated within the nanoparticle or selectively in a metal oxide shell of a core-shell nanoparticle. Methods of preparing the volume-labeled nanoparticles are also described.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-00OR22725

Assignee:: UT-Battelle, LLC (Oak Ridge, TN)

Patent Number(s):: 9,011,735

Application Number:: 12/981,886

OSTI ID:: 1178265

Resource Relation:: Patent File Date: 2010 Dec 30

Country of Publication:: United States

Language:: English

References (22)

A comparative study of non-covalent encapsulation methods for organic dyes into silica nanoparticles Auger, Aurélien; Samuel, Jorice; Poncelet, Olivier Nanoscale Research Letters, Vol. 6, Issue 1 https://doi.org/10.1186/1556-276X-6-328	journal	April 2011
Ultrabright Fluorescent Mesoporous Silica Nanoparticles Cho, Eun-Bum; Volkov, Dmytro O.; Sokolov, Igor Small, Vol. 6, Issue 20 https://doi.org/10.1002/smll.201001337	journal	September 2010
Bright and Stable Core−Shell Fluorescent Silica Nanoparticles Ow, Hooisweng; Larson, Daniel R.; Srivastava, Mamta Nano Letters, Vol. 5, Issue 1 https://doi.org/10.1021/nl0482478	journal	January 2005
Mesoporous silica nanoparticles deliver DNA and chemicals into plants Torney, François; Trewyn, Brian G.; Lin, Victor S. -Y. Nature Nanotechnology, Vol. 2, Issue 5 https://doi.org/10.1038/nnano.2007.108	journal	April 2007
Development of Organic-Dye-Doped Silica Nanoparticles in a Reverse Microemulsion Zhao, X.; Bagwe, R. P.; Tan, W. Advanced Materials, Vol. 16, Issue 2, p. 173-176 https://doi.org/10.1002/adma.200305622	journal	January 2004
Ultrasensitive detection of biomolecules with fluorescent dye-doped nanoparticles Lian, Wei; Litherland, Sally A.; Badrane, Hassan Analytical Biochemistry, Vol. 334, Issue 1, p. 135-144 https://doi.org/10.1016/j.ab.2004.08.005	journal	November 2004
Optimization of Dye-Doped Silica Nanoparticles Prepared Using a Reverse Microemulsion Method Bagwe, Rahul P.; Yang, Chaoyong; Hilliard, Lisa R. Langmuir, Vol. 20, Issue 19 https://doi.org/10.1021/la049137j	journal	September 2004
Bionanotechnology based on silica nanoparticles Tan, Weihong; Wang, Kemin; He, Xiaoxiao Medicinal Research Reviews, Vol. 24, Issue 5 https://doi.org/10.1002/med.20003	journal	January 2004
Adsorption and Encapsulation of Fluorescent Probes in Nanoparticles Makarova, Olga V.; Ostafin, Agnes E.; Miyoshi, Hirokazu The Journal of Physical Chemistry B, Vol. 103, Issue 43 https://doi.org/10.1021/jp9900786	journal	October 1999
Synthesis of Fluorescent, Monodisperse, Colloidal Silica Particles Nyffenegger, René; Quellet, Christian; Ricka, Jaroslav Journal of Colloid and Interface Science, Vol. 159, Issue 1 https://doi.org/10.1006/jcis.1993.1306	journal	August 1993
Synthesis and characterization of colloidal dispersions of fluorescent, monodisperse silica spheres Van Blaaderen, A.; Vrij, A. Langmuir, Vol. 8, Issue 12 https://doi.org/10.1021/la00048a013	journal	December 1992
Luminescent nanomaterials for biological labelling Wang, Feng; Tan, Wee Beng; Zhang, Yong Nanotechnology, Vol. 17, Issue 1 https://doi.org/10.1088/0957-4484/17/1/R01	journal	November 2005
FloDots: luminescent nanoparticles Yao, Gang; Wang, Lin; Wu, Yanrong Analytical and Bioanalytical Chemistry, Vol. 385, Issue 3 https://doi.org/10.1007/s00216-006-0452-z	journal	May 2006
Fluorescent core–shell silica nanoparticles: towards “Lab on a Particle” architectures for nanobiotechnology Burns, Andrew; Ow, Hooisweng; Wiesner, Ulrich Chem. Soc. Rev., Vol. 35, Issue 11, p. 1028-1042 https://doi.org/10.1039/B600562B	journal	September 2006
On the Development of Colloidal Nanoparticles towards Multifunctional Structures and their Possible Use for Biological Applications Pellegrino, Teresa; Kudera, Stefan; Liedl, Tim Small, Vol. 1, Issue 1 https://doi.org/10.1002/smll.200400071	journal	November 2004
Quantum dot bioconjugates for imaging, labelling and sensing Medintz, Igor L.; Uyeda, H. Tetsuo; Goldman, Ellen R. Nature Materials, Vol. 4, Issue 6, p. 435-446 https://doi.org/10.1038/nmat1390	journal	June 2005
Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance Hirsch, L. R.; Stafford, R. J.; Bankson, J. A. Proceedings of the National Academy of Sciences, Vol. 100, Issue 23, p. 13549-13554 https://doi.org/10.1073/pnas.2232479100	journal	November 2003
Core-shell magnetic nanoparticles and nanocomposite materials formed therefrom Yang, Hong; Teng, Xiaowei https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7029514 US Patent Document 7,029,514	patent	April 2006
Fluorescent-magnetic nanoparticles with core-shell structure Carpenter, Everett E.; Carpenter, Vincent https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7235228 US Patent Document 7,235,228	patent	June 2007
Core-shell magnetic nanoparticles comprising an inner-transition element Cho, Hui-Ju; Shih, Sheng-Ming; Lin, Yuh-Jiuan https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7396589 US Patent Document 7,396,589	patent	July 2008
Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring Bao, Gang; Nie, Shuming; Nitin, Nitin https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7459145 US Patent Document 7,459,145	patent	December 2008
Core-shell fluorescent nanoparticles Wang, Xiaorong; Rademacher, Christine https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7597959 US Patent Document 7,597,959	patent	October 2009

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