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Title: Protocells and their use for targeted delivery of multicomponent cargos to cancer cells

Abstract

Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.

Inventors:
; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1177123
Patent Number(s):
8,992,984
Application Number:
12/909,572
Assignee:
STC.UNM (Albuquergue, NM) SSO
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Resource Relation:
Patent File Date: 2010 Oct 21
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Brinker, C Jeffrey, Ashley, Carlee Erin, Jiang, Xingmao, Liu, Juewen, Peabody, David S, Wharton, Walker Richard, Carnes, Eric, Chackerian, Bryce, and Willman, Cheryl L. Protocells and their use for targeted delivery of multicomponent cargos to cancer cells. United States: N. p., 2015. Web.
Brinker, C Jeffrey, Ashley, Carlee Erin, Jiang, Xingmao, Liu, Juewen, Peabody, David S, Wharton, Walker Richard, Carnes, Eric, Chackerian, Bryce, & Willman, Cheryl L. Protocells and their use for targeted delivery of multicomponent cargos to cancer cells. United States.
Brinker, C Jeffrey, Ashley, Carlee Erin, Jiang, Xingmao, Liu, Juewen, Peabody, David S, Wharton, Walker Richard, Carnes, Eric, Chackerian, Bryce, and Willman, Cheryl L. Tue . "Protocells and their use for targeted delivery of multicomponent cargos to cancer cells". United States. doi:. https://www.osti.gov/servlets/purl/1177123.
@article{osti_1177123,
title = {Protocells and their use for targeted delivery of multicomponent cargos to cancer cells},
author = {Brinker, C Jeffrey and Ashley, Carlee Erin and Jiang, Xingmao and Liu, Juewen and Peabody, David S and Wharton, Walker Richard and Carnes, Eric and Chackerian, Bryce and Willman, Cheryl L},
abstractNote = {Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 31 00:00:00 EDT 2015},
month = {Tue Mar 31 00:00:00 EDT 2015}
}

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Works referenced in this record:

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