skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Parallel macromolecular delivery and biochemical/electrochemical interface to cells employing nanostructures

Abstract

Systems and methods are described for parallel macromolecular delivery and biochemical/electrochemical interface to whole cells employing carbon nanostructures including nanofibers and nanotubes. A method includes providing a first material on at least a first portion of a first surface of a first tip of a first elongated carbon nanostructure; providing a second material on at least a second portion of a second surface of a second tip of a second elongated carbon nanostructure, the second elongated carbon nanostructure coupled to, and substantially parallel to, the first elongated carbon nanostructure; and penetrating a boundary of a biological sample with at least one member selected from the group consisting of the first tip and the second tip.

Inventors:
; ; ; ; ;
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1177079
Patent Number(s):
8,993,327
Application Number:
10/408,294
Assignee:
UT-Battelle, LLC (Oak Ridge, TN) ORO
DOE Contract Number:  
AC05-00OR22725
Resource Type:
Patent
Resource Relation:
Patent File Date: 2003 Apr 07
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY

Citation Formats

McKnight, Timothy E, Melechko, Anatoli V, Griffin, Guy D, Guillorn, Michael A, Merkulov, Vladimir L, and Simpson, Michael L. Parallel macromolecular delivery and biochemical/electrochemical interface to cells employing nanostructures. United States: N. p., 2015. Web.
McKnight, Timothy E, Melechko, Anatoli V, Griffin, Guy D, Guillorn, Michael A, Merkulov, Vladimir L, & Simpson, Michael L. Parallel macromolecular delivery and biochemical/electrochemical interface to cells employing nanostructures. United States.
McKnight, Timothy E, Melechko, Anatoli V, Griffin, Guy D, Guillorn, Michael A, Merkulov, Vladimir L, and Simpson, Michael L. Tue . "Parallel macromolecular delivery and biochemical/electrochemical interface to cells employing nanostructures". United States. doi:. https://www.osti.gov/servlets/purl/1177079.
@article{osti_1177079,
title = {Parallel macromolecular delivery and biochemical/electrochemical interface to cells employing nanostructures},
author = {McKnight, Timothy E and Melechko, Anatoli V and Griffin, Guy D and Guillorn, Michael A and Merkulov, Vladimir L and Simpson, Michael L},
abstractNote = {Systems and methods are described for parallel macromolecular delivery and biochemical/electrochemical interface to whole cells employing carbon nanostructures including nanofibers and nanotubes. A method includes providing a first material on at least a first portion of a first surface of a first tip of a first elongated carbon nanostructure; providing a second material on at least a second portion of a second surface of a second tip of a second elongated carbon nanostructure, the second elongated carbon nanostructure coupled to, and substantially parallel to, the first elongated carbon nanostructure; and penetrating a boundary of a biological sample with at least one member selected from the group consisting of the first tip and the second tip.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 31 00:00:00 EDT 2015},
month = {Tue Mar 31 00:00:00 EDT 2015}
}

Patent:

Save / Share:

Works referenced in this record:

Whole-cell biocomputing
journal, August 2001

  • Simpson, Michael L.; Sayler, Gary S.; Fleming, James T.
  • Trends in Biotechnology, Vol. 19, Issue 8, p. 317-323
  • DOI: 10.1016/S0167-7799(01)01691-2

Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
journal, September 1998


Semiconductor Nanocrystals as Fluorescent Biological Labels
patent, September 1998


Natural alleles at a tomato fruit size quantitative trait locus differ by heterochronic regulatory mutations
journal, October 2002

  • Cong, B.; Liu, J.; Tanksley, S. D.
  • Proceedings of the National Academy of Sciences, Vol. 99, Issue 21, p. 13606-13611
  • DOI: 10.1073/pnas.172520999

The use of Chinese hamster ovary cells to quantify specific locus mutation and to determine mutagenicity of chemicals: A report of the GENE-TOX program
journal, March 1981

  • Hsie, A. W.; Casciano, D. A.; Couch, D. B.
  • Mutation Research/Reviews in Genetic Toxicology, Vol. 86, Issue 2, p. 193-214
  • DOI: 10.1016/0165-1110(81)90024-5

Electrochemically induced adsorption of radio-labeled DNA on gold and HOPG substrates for STM investigations
journal, December 1991


Major limitations in the use of cationic liposomes for DNA delivery
journal, March 1998

  • Filion, Mario C.; Phillips, Nigel C.
  • International Journal of Pharmaceutics, Vol. 162, Issue 1-2, p. 159-170
  • DOI: 10.1016/S0378-5173(97)00423-7

Micromachined interfaces: new approaches in cell immunoisolation and biomolecular separation
journal, October 2000


Field emission properties of different forms of carbon
journal, June 2001

  • Merkulov, Vladimir I.; Lowndes, Douglas H.; Baylor, Larry R.
  • Solid-State Electronics, Vol. 45, Issue 6, p. 949-956
  • DOI: 10.1016/S0038-1101(01)00036-3