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Title: Non-immunogenic, hydrophilic/cationic block copolymers and uses thereof

Abstract

The present invention provides novel non-immunogenic, hydrophilic/cationic block copolymers comprising a neutral-hydrophilic polymer and a cationic polymer, wherein both polymers have well-defined chain-end functionality. A representative example of such a block copolymer comprises poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) and poly(N-[3-(dimethylamino)propyl]methacrylamide) (PDMAPMA). Also provided is a synthesis method thereof in aqueous media via reversible addition fragmentation chain transfer (RAFT) polymerization. Further provided are uses of these block copolymers as drug delivery vehicles and protection agents.

Inventors:
; ;
Publication Date:
Research Org.:
Univ. of Southern Mississippi, Hattiesburg, MS (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1176304
Patent Number(s):
7,718,432
Application Number:
11/725,964
Assignee:
The University of Southern Mississippi (Hattiesburg, MS)
DOE Contract Number:  
FC26-01BC15317
Resource Type:
Patent
Resource Relation:
Patent File Date: 2007 Mar 20
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 60 APPLIED LIFE SCIENCES

Citation Formats

Scales, Charles W., Huang, Faqing, and McCormick, Charles L. Non-immunogenic, hydrophilic/cationic block copolymers and uses thereof. United States: N. p., 2010. Web.
Scales, Charles W., Huang, Faqing, & McCormick, Charles L. Non-immunogenic, hydrophilic/cationic block copolymers and uses thereof. United States.
Scales, Charles W., Huang, Faqing, and McCormick, Charles L. Tue . "Non-immunogenic, hydrophilic/cationic block copolymers and uses thereof". United States. https://www.osti.gov/servlets/purl/1176304.
@article{osti_1176304,
title = {Non-immunogenic, hydrophilic/cationic block copolymers and uses thereof},
author = {Scales, Charles W. and Huang, Faqing and McCormick, Charles L.},
abstractNote = {The present invention provides novel non-immunogenic, hydrophilic/cationic block copolymers comprising a neutral-hydrophilic polymer and a cationic polymer, wherein both polymers have well-defined chain-end functionality. A representative example of such a block copolymer comprises poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) and poly(N-[3-(dimethylamino)propyl]methacrylamide) (PDMAPMA). Also provided is a synthesis method thereof in aqueous media via reversible addition fragmentation chain transfer (RAFT) polymerization. Further provided are uses of these block copolymers as drug delivery vehicles and protection agents.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {5}
}

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