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Title: Glycoprotein synthesis

Abstract

Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.

Inventors:
; ;
Publication Date:
Research Org.:
The Scripps Research Inst., La Jolla, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1176126
Patent Number(s):
7,183,082
Application Number:
11/093,798
Assignee:
The Scripps Research Institute (La Jolla, CA) OSTI
DOE Contract Number:
FG03-00ER45812
Resource Type:
Patent
Resource Relation:
Patent File Date: 2007 Feb 27
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Schultz, Peter G., Wang, Lei, and Zhang, Zhiwen. Glycoprotein synthesis. United States: N. p., 2007. Web.
Schultz, Peter G., Wang, Lei, & Zhang, Zhiwen. Glycoprotein synthesis. United States.
Schultz, Peter G., Wang, Lei, and Zhang, Zhiwen. Tue . "Glycoprotein synthesis". United States. doi:. https://www.osti.gov/servlets/purl/1176126.
@article{osti_1176126,
title = {Glycoprotein synthesis},
author = {Schultz, Peter G. and Wang, Lei and Zhang, Zhiwen},
abstractNote = {Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 27 00:00:00 EST 2007},
month = {Tue Feb 27 00:00:00 EST 2007}
}

Patent:

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