Methods for assisting recovery of damaged brain and spinal cord using arrays of X-ray microplanar beams
A method of assisting recovery of an injury site of brain or spinal cord injury includes providing a therapeutic dose of X-ray radiation to the injury site through an array of parallel microplanar beams. The dose at least temporarily removes regeneration inhibitors from the irradiated regions. Substantially unirradiated cells surviving between the microplanar beams migrate to the in-beam irradiated portion and assist in recovery. The dose may be administered in dose fractions over several sessions, separated in time, using angle-variable intersecting microbeam arrays (AVIMA). Additional doses may be administered by varying the orientation of the microplanar beams. The method may be enhanced by injecting stem cells into the injury site.
- Research Organization:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC02-98CH10886
- Assignee:
- Brookhaven Science Associates, LLC (Upton, NY)
- Patent Number(s):
- 7,158,607
- Application Number:
- 11/054,000
- OSTI ID:
- 1176058
- Country of Publication:
- United States
- Language:
- English
Beneficial effects of x-irradiation on recovery of lesioned mammalian central nervous tissue.
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journal | December 1990 |
Fractionated radiation facilitates repair and functional motor recovery after spinal cord transection in rat
|
journal | June 2001 |
Structural recovery in lesioned adult mammalian spinal cord by x-irradiation of the lesion site.
|
journal | October 1996 |
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