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Title: Methods for assisting recovery of damaged brain and spinal cord using arrays of X-ray microplanar beams

Abstract

A method of assisting recovery of an injury site of brain or spinal cord injury includes providing a therapeutic dose of X-ray radiation to the injury site through an array of parallel microplanar beams. The dose at least temporarily removes regeneration inhibitors from the irradiated regions. Substantially unirradiated cells surviving between the microplanar beams migrate to the in-beam irradiated portion and assist in recovery. The dose may be administered in dose fractions over several sessions, separated in time, using angle-variable intersecting microbeam arrays (AVIMA). Additional doses may be administered by varying the orientation of the microplanar beams. The method may be enhanced by injecting stem cells into the injury site.

Inventors:
;
Publication Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1176058
Patent Number(s):
7,158,607
Application Number:
11/054,000
Assignee:
Brookhaven Science Associates, LLC (Upton, NY)
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Dilmanian, F. Avraham, and McDonald, III, John W. Methods for assisting recovery of damaged brain and spinal cord using arrays of X-ray microplanar beams. United States: N. p., 2007. Web.
Dilmanian, F. Avraham, & McDonald, III, John W. Methods for assisting recovery of damaged brain and spinal cord using arrays of X-ray microplanar beams. United States.
Dilmanian, F. Avraham, and McDonald, III, John W. Tue . "Methods for assisting recovery of damaged brain and spinal cord using arrays of X-ray microplanar beams". United States. https://www.osti.gov/servlets/purl/1176058.
@article{osti_1176058,
title = {Methods for assisting recovery of damaged brain and spinal cord using arrays of X-ray microplanar beams},
author = {Dilmanian, F. Avraham and McDonald, III, John W.},
abstractNote = {A method of assisting recovery of an injury site of brain or spinal cord injury includes providing a therapeutic dose of X-ray radiation to the injury site through an array of parallel microplanar beams. The dose at least temporarily removes regeneration inhibitors from the irradiated regions. Substantially unirradiated cells surviving between the microplanar beams migrate to the in-beam irradiated portion and assist in recovery. The dose may be administered in dose fractions over several sessions, separated in time, using angle-variable intersecting microbeam arrays (AVIMA). Additional doses may be administered by varying the orientation of the microplanar beams. The method may be enhanced by injecting stem cells into the injury site.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {1}
}

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Works referenced in this record:

Beneficial effects of x-irradiation on recovery of lesioned mammalian central nervous tissue.
journal, December 1990

  • Kalderon, N.; Alfieri, A. A.; Fuks, Z.
  • Proceedings of the National Academy of Sciences, Vol. 87, Issue 24
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Fractionated radiation facilitates repair and functional motor recovery after spinal cord transection in rat
journal, June 2001


Structural recovery in lesioned adult mammalian spinal cord by x-irradiation of the lesion site.
journal, October 1996

  • Kalderon, N.; Fuks, Z.
  • Proceedings of the National Academy of Sciences, Vol. 93, Issue 20
  • DOI: 10.1073/pnas.93.20.11179