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Title: Structure of adenovirus bound to cellular receptor car

Abstract

Disclosed is a mutant CAR-DI-binding adenovirus which has a genome comprising one or more mutations in sequences which encode the fiber protein knob domain wherein the mutation causes the encoded viral particle to have a significantly weakened binding affinity for CAR-DI relative to wild-type adenovirus. Such mutations may be in sequences which encode either the AB loop, or the HI loop of the fiber protein knob domain. Specific residues and mutations are described. Also disclosed is a method for generating a mutant adenovirus which is characterized by a receptor binding affinity or specificity which differs substantially from wild type.

Inventors:
Publication Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1176056
Patent Number(s):
7,157,266
Application Number:
10/218,419
Assignee:
Brookhaven Science Associates LLC (Upton, NY) BNL
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Freimuth, Paul I. Structure of adenovirus bound to cellular receptor car. United States: N. p., 2007. Web.
Freimuth, Paul I. Structure of adenovirus bound to cellular receptor car. United States.
Freimuth, Paul I. Tue . "Structure of adenovirus bound to cellular receptor car". United States. doi:. https://www.osti.gov/servlets/purl/1176056.
@article{osti_1176056,
title = {Structure of adenovirus bound to cellular receptor car},
author = {Freimuth, Paul I.},
abstractNote = {Disclosed is a mutant CAR-DI-binding adenovirus which has a genome comprising one or more mutations in sequences which encode the fiber protein knob domain wherein the mutation causes the encoded viral particle to have a significantly weakened binding affinity for CAR-DI relative to wild-type adenovirus. Such mutations may be in sequences which encode either the AB loop, or the HI loop of the fiber protein knob domain. Specific residues and mutations are described. Also disclosed is a method for generating a mutant adenovirus which is characterized by a receptor binding affinity or specificity which differs substantially from wild type.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 02 00:00:00 EST 2007},
month = {Tue Jan 02 00:00:00 EST 2007}
}

Patent:

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