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Title: Advanced synchronous luminescence imaging for chemical and medical diagnostics

Abstract

A diagnostic method and associated system includes the steps of exposing at least one sample location with excitation radiation through a single optical waveguide or a single optical waveguide bundle, wherein the sample emits emission radiation in response to the excitation radiation. The same single optical waveguide or the single optical waveguide bundle receives at least a portion of the emission radiation from the sample, thus providing co-registration of the excitation radiation and the emission radiation. The wavelength of the excitation radiation and emission radiation is synchronously scanned to produce a spectrum upon which an image can be formed. An increased emission signal is generated by the enhanced overlap of the excitation and emission focal volumes provided by co-registration of the excitation and emission signals thus increasing the sensitivity as well as decreasing the exposure time necessary to obtain an image.

Inventors:
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175906
Patent Number(s):
7,103,402
Application Number:
10/677,703
Assignee:
UT-Battelle, LLC (Oak Ridge, TN)
DOE Contract Number:  
AC05-00OR22725
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Vo-Dinh, Tuan. Advanced synchronous luminescence imaging for chemical and medical diagnostics. United States: N. p., 2006. Web.
Vo-Dinh, Tuan. Advanced synchronous luminescence imaging for chemical and medical diagnostics. United States.
Vo-Dinh, Tuan. 2006. "Advanced synchronous luminescence imaging for chemical and medical diagnostics". United States. https://www.osti.gov/servlets/purl/1175906.
@article{osti_1175906,
title = {Advanced synchronous luminescence imaging for chemical and medical diagnostics},
author = {Vo-Dinh, Tuan},
abstractNote = {A diagnostic method and associated system includes the steps of exposing at least one sample location with excitation radiation through a single optical waveguide or a single optical waveguide bundle, wherein the sample emits emission radiation in response to the excitation radiation. The same single optical waveguide or the single optical waveguide bundle receives at least a portion of the emission radiation from the sample, thus providing co-registration of the excitation radiation and the emission radiation. The wavelength of the excitation radiation and emission radiation is synchronously scanned to produce a spectrum upon which an image can be formed. An increased emission signal is generated by the enhanced overlap of the excitation and emission focal volumes provided by co-registration of the excitation and emission signals thus increasing the sensitivity as well as decreasing the exposure time necessary to obtain an image.},
doi = {},
url = {https://www.osti.gov/biblio/1175906}, journal = {},
number = ,
volume = ,
place = {United States},
year = {2006},
month = {9}
}

Works referenced in this record:

Multicomponent analysis by synchronous luminescence spectrometry
journal, March 1978


Diffraction tomographic imaging with photon density waves: an explicit solution
journal, January 1998


Synchronous Luminescence Spectroscopy: Methodology and Applicability
journal, September 1982


Laser-Induced Differential Fluorescence for Cancer Diagnosis without Biopsy
journal, January 1997


Fast Scanning Synchronous Luminescence Spectrometer Based on Acousto-Optic Tunable Filters
journal, November 1995