Carboranylporphyrins and uses thereof

Wu, Haitao; Miura, Michiko

Carboranylporphyrins and uses thereof

Patent · 06 February 2006

OSTI ID:1175641

Wu, Haitao; Miura, Michiko

The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing 5, 10, 15, 20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these carborane-containing tetraphenyl porphyrin compounds to methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-98CH10886

Assignee:: Brookhaven Science Associates, LLC (Upton, NY)

Patent Number(s):: 6,995,260

Application Number:: 10/848,741

OSTI ID:: 1175641

Country of Publication:: United States

Language:: English

References (18)

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